1z7k

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(New page: 200px<br /><applet load="1z7k" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z7k, resolution 1.90&Aring;" /> '''Crystal Structure of...)
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[[Image:1z7k.gif|left|200px]]<br /><applet load="1z7k" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1z7k, resolution 1.90&Aring;" />
 
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'''Crystal Structure of Trypsin- Ovomucoid turkey egg white inhibitor complex'''<br />
 
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==Overview==
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==Crystal Structure of Trypsin- Ovomucoid turkey egg white inhibitor complex==
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Crystal structure of the complex between porcine beta-trypsin and the, second domain of the Kazal-type ovomucoid turkey egg white trypsin, inhibitor (OMTKY2) has been determined at 1.9A resolution. A peptide, fragment from the first domain has been crystallized with the complex., Restrained-refinement of the structure led to an R-factor of 0.19 for the, 32206 reflections. OMTKY2 exhibits the canonical Kazal-type fold with a, central alpha-helix and a short two-stranded anti-parallel beta-sheet. The, carbonyl carbon of the reactive site prefers trigonal geometry. The, reactive site loop geometry of the inhibitor is complementary to the, surface and charge of the binding site in beta-trypsin.
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<StructureSection load='1z7k' size='340' side='right'caption='[[1z7k]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1z7k]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1r0t 1r0t]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z7K FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7k OCA], [https://pdbe.org/1z7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z7k RCSB], [https://www.ebi.ac.uk/pdbsum/1z7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRYP_PIG TRYP_PIG]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z7/1z7k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z7k ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1Z7K is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure superseeds the now removed PDB entry 1R0T. Active as [http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Z7K OCA].
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*[[Trypsin 3D structures|Trypsin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of trypsin-turkey egg white inhibitor complex., Ibrahim BS, Pattabhi V, Biochem Biophys Res Commun. 2004 Jan 2;313(1):8-16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14672690 14672690]
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[[Category: Large Structures]]
[[Category: Meleagris gallopavo]]
[[Category: Meleagris gallopavo]]
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[[Category: Protein complex]]
 
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Trypsin]]
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[[Category: Pattabhi V]]
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[[Category: Ibrahim, B.Syed.]]
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[[Category: Syed Ibrahim B]]
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[[Category: Pattabhi, V.]]
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[[Category: di-nag]]
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[[Category: hydrolase]]
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[[Category: protease inhibitor]]
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[[Category: serine protease]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 07:16:58 2007''
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Current revision

Crystal Structure of Trypsin- Ovomucoid turkey egg white inhibitor complex

PDB ID 1z7k

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