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1mvf

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{{Seed}}
 
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[[Image:1mvf.png|left|200px]]
 
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==MazE addiction antidote==
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The line below this paragraph, containing "STRUCTURE_1mvf", creates the "Structure Box" on the page.
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<StructureSection load='1mvf' size='340' side='right'caption='[[1mvf]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mvf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius] and [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MVF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvf OCA], [https://pdbe.org/1mvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mvf RCSB], [https://www.ebi.ac.uk/pdbsum/1mvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mvf ProSAT]</span></td></tr>
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{{STRUCTURE_1mvf| PDB=1mvf | SCENE= }}
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</table>
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== Function ==
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===MazE addiction antidote===
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[https://www.uniprot.org/uniprot/MAZE_ECOLI MAZE_ECOLI] Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that binds to the MazF mRNA interferase toxin and neutralizes its endoribonuclease activity. Is considered to be an 'addiction' molecule as the cell will die in its absence. The endoribonuclease activity (MazF, a toxin) is inhibited by the labile cognate antitoxin MazE. Toxicity results when the levels of MazE decrease in the cell, leading to mRNA degradation. This effect can be rescued by expression of MazE, but after 6 hours in rich medium the overexpression of MazF leads to programmed cell death. Cell growth and viability are not affected when MazF and MazE are coexpressed. Both MazE and MazE-MazF bind to the promoter region of the mazE-mazF operon to inhibit their transcription. Cell death governed by the MazE-MazF and DinJ-YafQ TA modules seems to play a role in biofilm formation, while MazE-MazF is also implicated in cell death in liquid media.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 12743116 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mv/1mvf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_12743116}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mvf ConSurf].
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1MVF is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVF OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:12743116</ref><references group="xtra"/>
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[[Category: Camelus dromedarius]]
[[Category: Camelus dromedarius]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Engelberg-Kulka, H.]]
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[[Category: Large Structures]]
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[[Category: Glaser, G.]]
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[[Category: Engelberg-Kulka H]]
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[[Category: Laeremans, T.]]
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[[Category: Glaser G]]
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[[Category: Lah, J.]]
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[[Category: Laeremans T]]
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[[Category: Loris, R.]]
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[[Category: Lah J]]
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[[Category: Marianovsky, I.]]
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[[Category: Loris R]]
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[[Category: Muyldermans, S.]]
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[[Category: Marianovsky I]]
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[[Category: Wyns, L.]]
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[[Category: Muyldermans S]]
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[[Category: Addiction antidote]]
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[[Category: Wyns L]]
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[[Category: Camel antibody]]
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[[Category: Plasmid addiction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:03:44 2009''
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Current revision

MazE addiction antidote

PDB ID 1mvf

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