1r4r

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{{Seed}}
 
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[[Image:1r4r.png|left|200px]]
 
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==Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA==
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The line below this paragraph, containing "STRUCTURE_1r4r", creates the "Structure Box" on the page.
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<StructureSection load='1r4r' size='340' side='right'caption='[[1r4r]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1r4r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R4R FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1r4r| PDB=1r4r | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r4r OCA], [https://pdbe.org/1r4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r4r RCSB], [https://www.ebi.ac.uk/pdbsum/1r4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r4r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GCR_RAT GCR_RAT] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation (By similarity).<ref>PMID:12917342</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/1r4r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r4r ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Two crystal structures of the glucocorticoid receptor DNA-binding domain complexed with DNA are reported. The domain has a globular fold which contains two Zn-nucleated substructures of distinct conformation and function. When it binds DNA, the domain dimerizes, placing the subunits in adjacent major grooves. In one complex, the DNA has the symmetrical consensus target sequence; in the second, the central spacing between the target's half-sites is larger by one base pair. This results in one subunit interacting specifically with the consensus target half-site and the other nonspecifically with a noncognate element. The DNA-induced dimer fixes the separation of the subunits' recognition surfaces so that the spacing between the half-sites becomes a critical feature of the target sequence's identity.
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===Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA===
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Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA.,Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR, Sigler PB Nature. 1991 Aug 8;352(6335):497-505. PMID:1865905<ref>PMID:1865905</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1r4r" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_1865905}}, adds the Publication Abstract to the page
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*[[Glucocorticoid receptor 3D structures|Glucocorticoid receptor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 1865905 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_1865905}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1R4R is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R4R OCA].
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==Reference==
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<ref group="xtra">PMID:1865905</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Freedman, L P.]]
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[[Category: Freedman LP]]
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[[Category: Luisi, B F.]]
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[[Category: Luisi BF]]
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[[Category: Otwinowski, Z.]]
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[[Category: Otwinowski Z]]
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[[Category: Sigler, P B.]]
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[[Category: Sigler PB]]
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[[Category: Xu, W X.]]
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[[Category: Xu WX]]
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[[Category: Yamamoto, K R.]]
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[[Category: Yamamoto KR]]
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[[Category: Glucocorticoid]]
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[[Category: Gr]]
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[[Category: Ir3]]
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[[Category: Protein-dna complex]]
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[[Category: Steroid receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:06:30 2009''
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Current revision

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

PDB ID 1r4r

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