1lxy

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{{Seed}}
 
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[[Image:1lxy.png|left|200px]]
 
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==Crystal Structure of Arginine Deiminase covalently linked with L-citrulline==
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The line below this paragraph, containing "STRUCTURE_1lxy", creates the "Structure Box" on the page.
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<StructureSection load='1lxy' size='340' side='right'caption='[[1lxy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lxy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycoplasmopsis_arginini Mycoplasmopsis arginini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LXY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIR:CITRULLINE'>CIR</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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{{STRUCTURE_1lxy| PDB=1lxy | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lxy OCA], [https://pdbe.org/1lxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lxy RCSB], [https://www.ebi.ac.uk/pdbsum/1lxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lxy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARCA_MYCAR ARCA_MYCAR]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lx/1lxy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lxy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Arginine deiminase (ADI), an enzyme that hydrolyzes arginine to generate energy in many parasitic microorganisms, has potent anticancer activities and can halt growth of solid tumors. We determined the crystal structure of ADI from Mycoplasma arginini in two different forms (1.6 and 2.0 A resolution) using multiple isomorphous replacement. ADI shares common structural features with the arginine-catabolizing enzymes Arg:Gly amidinotransferase and dimethylarginine dimethyl-aminohydrolase; ADI contains an additional domain of five helices. The scissile C-N bonds of the substrates and the catalytic triads (Cys398-His269-Glu213 of ADI) for the three enzymes superimpose on each other. The ADI structure from form I crystals corresponds to a tetrahedral intermediate with four heteroatoms (1S, 2N, 1O) covalently bonded to the reaction-center carbon. The structure from form II crystals represents an amidino-enzyme complex; the reaction-center carbon is covalently bonded to Cys398 sulfur and two nitrogens, and the reacting water molecule is only 2.54 A away.
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===Crystal Structure of Arginine Deiminase covalently linked with L-citrulline===
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Crystal structures of arginine deiminase with covalent reaction intermediates; implications for catalytic mechanism.,Das K, Butler GH, Kwiatkowski V, Clark AD Jr, Yadav P, Arnold E Structure. 2004 Apr;12(4):657-67. PMID:15062088<ref>PMID:15062088</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15062088}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1lxy" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15062088 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15062088}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1LXY is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycoplasma_arginini Mycoplasma arginini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LXY OCA].
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[[Category: Mycoplasmopsis arginini]]
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[[Category: Arnold E]]
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==Reference==
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[[Category: Buttler GH]]
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<ref group="xtra">PMID:15062088</ref><references group="xtra"/>
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[[Category: Das K]]
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[[Category: Arginine deiminase]]
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[[Category: Kwiatkowski V]]
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[[Category: Mycoplasma arginini]]
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[[Category: Yadav P]]
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[[Category: Arnold, E.]]
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[[Category: Buttler, G H.]]
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[[Category: Das, K.]]
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[[Category: Kwiatkowski, V.]]
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[[Category: Yadav, P.]]
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[[Category: 5-fold pseudo-symmetric domain]]
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[[Category: 5-helix bundle domain]]
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[[Category: Deiminase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:12:27 2009''
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Current revision

Crystal Structure of Arginine Deiminase covalently linked with L-citrulline

PDB ID 1lxy

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