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1zav

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(New page: 200px<br /><applet load="1zav" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zav, resolution 1.9&Aring;" /> '''Ribosomal Protein L10...)
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[[Image:1zav.gif|left|200px]]<br /><applet load="1zav" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1zav, resolution 1.9&Aring;" />
 
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'''Ribosomal Protein L10-L12(NTD) Complex, Space Group P21'''<br />
 
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==Overview==
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==Ribosomal Protein L10-L12(NTD) Complex, Space Group P21==
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The L7/12 stalk of the large subunit of bacterial ribosomes encompasses, protein L10 and multiple copies of L7/12. We present crystal structures of, Thermotoga maritima L10 in complex with three L7/12 N-terminal-domain, dimers, refine the structure of an archaeal L10E N-terminal domain on the, 50S subunit, and identify these elements in cryo-electron-microscopic, reconstructions of Escherichia coli ribosomes. The mobile C-terminal helix, alpha8 of L10 carries three L7/12 dimers in T. maritima and two in E., coli, in concordance with the different length of helix alpha8 of L10 in, these organisms. The stalk is organized into three elements (stalk base, L10 helix alpha8-L7/12 N-terminal-domain complex, and L7/12 C-terminal, domains) linked by flexible connections. Highly mobile L7/12 C-terminal, domains promote recruitment of translation factors to the ribosome and, stimulate GTP hydrolysis by the ribosome bound factors through, stabilization of their active GTPase conformation.
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<StructureSection load='1zav' size='340' side='right'caption='[[1zav]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1zav]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZAV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zav OCA], [https://pdbe.org/1zav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zav RCSB], [https://www.ebi.ac.uk/pdbsum/1zav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zav ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL10_THEMA RL10_THEMA] Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors (such as IF-2, EF-Tu, EF-G and RF3) (Probable).[HAMAP-Rule:MF_00362]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/za/1zav_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zav ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1ZAV is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ZAV OCA].
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*[[Ribosomal protein L10|Ribosomal protein L10]]
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*[[Ribosomal protein L7/L12|Ribosomal protein L7/L12]]
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==Reference==
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__TOC__
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Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation., Diaconu M, Kothe U, Schlunzen F, Fischer N, Harms JM, Tonevitsky AG, Stark H, Rodnina MV, Wahl MC, Cell. 2005 Jul 1;121(7):991-1004. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15989950 15989950]
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</StructureSection>
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[[Category: Protein complex]]
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[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: Diaconu, M.]]
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[[Category: Diaconu M]]
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[[Category: Fischer, N.]]
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[[Category: Fischer N]]
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[[Category: Harms, J.M.]]
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[[Category: Harms JM]]
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[[Category: Kothe, U.]]
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[[Category: Kothe U]]
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[[Category: Rodnina, M.V.]]
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[[Category: Rodnina MV]]
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[[Category: Schluenzen, F.]]
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[[Category: Schluenzen F]]
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[[Category: Stark, H.]]
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[[Category: Stark H]]
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[[Category: Tonevitski, A.G.]]
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[[Category: Tonevitski AG]]
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[[Category: Wahl, M.C.]]
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[[Category: Wahl MC]]
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[[Category: cryo-electron microscopy]]
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[[Category: gtpase stimulation]]
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[[Category: l10-l12 complex structure]]
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[[Category: l10e structure]]
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[[Category: l7/12 ribosomal stalk]]
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[[Category: mechanism of translation]]
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[[Category: rapid kinetics]]
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[[Category: ribosome structure and function]]
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[[Category: thiostrepton loop of 23s rrna]]
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[[Category: translation factor recruitment]]
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[[Category: x-ray crystallography]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 07:21:04 2007''
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Current revision

Ribosomal Protein L10-L12(NTD) Complex, Space Group P21

PDB ID 1zav

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