1hbx

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{{Seed}}
 
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[[Image:1hbx.png|left|200px]]
 
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==Ternary Complex of SAP-1 and SRF with specific SRE DNA==
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The line below this paragraph, containing "STRUCTURE_1hbx", creates the "Structure Box" on the page.
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<StructureSection load='1hbx' size='340' side='right'caption='[[1hbx]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hbx]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HBX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hbx OCA], [https://pdbe.org/1hbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hbx RCSB], [https://www.ebi.ac.uk/pdbsum/1hbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hbx ProSAT]</span></td></tr>
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{{STRUCTURE_1hbx| PDB=1hbx | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SRF_HUMAN SRF_HUMAN] SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hb/1hbx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hbx ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The serum response element (SRE) is found in several immediate-early gene promoters. This DNA sequence is necessary and sufficient for rapid transcriptional induction of the human c-fos proto-oncogene in response to stimuli external to the cell. Full activation of the SRE requires the cooperative binding of a ternary complex factor (TCF) and serum response factor (SRF) to their specific DNA sites. The X-ray structure of the human SAP-1-SRF-SRE DNA ternary complex was determined (Protein Data Bank code 1hbx). It shows SAP-1 TCF bound to SRF through interactions between the SAP-1 B-box and SRF MADS domain in addition to contacts between their respective DNA-binding motifs. The SAP-1 B-box is part of a flexible linker of which 21 amino acids become ordered upon ternary complex formation. Comparison with a similar region from the yeast MATalpha2-MCM1-DNA complex suggests a common binding motif through which MADS-box proteins may interact with additional factors such as Fli-1.
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===TERNARY COMPLEX OF SAP-1 AND SRF WITH SPECIFIC SRE DNA===
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The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex.,Hassler M, Richmond TJ EMBO J. 2001 Jun 15;20(12):3018-28. PMID:11406578<ref>PMID:11406578</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11406578}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1hbx" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11406578 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11406578}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1HBX is a 10 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HBX OCA].
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==Reference==
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<ref group="xtra">PMID:11406578</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hassler, M.]]
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[[Category: Large Structures]]
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[[Category: Richmond, T J.]]
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[[Category: Hassler M]]
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[[Category: Gene regulation]]
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[[Category: Richmond TJ]]
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[[Category: Serum response factor]]
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[[Category: Ternary complex factor]]
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[[Category: Transcription complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:40:49 2009''
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Current revision

Ternary Complex of SAP-1 and SRF with specific SRE DNA

PDB ID 1hbx

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