1bd9

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{{Seed}}
 
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[[Image:1bd9.png|left|200px]]
 
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==HUMAN PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN==
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The line below this paragraph, containing "STRUCTURE_1bd9", creates the "Structure Box" on the page.
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<StructureSection load='1bd9' size='340' side='right'caption='[[1bd9]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bd9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BD9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BD9 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bd9 OCA], [https://pdbe.org/1bd9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bd9 RCSB], [https://www.ebi.ac.uk/pdbsum/1bd9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bd9 ProSAT]</span></td></tr>
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{{STRUCTURE_1bd9| PDB=1bd9 | SCENE= }}
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</table>
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== Function ==
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===HUMAN PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN===
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[https://www.uniprot.org/uniprot/PEBP1_HUMAN PEBP1_HUMAN] Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.<ref>PMID:18294816</ref> HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).<ref>PMID:18294816</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 9782050 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bd/1bd9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_9782050}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bd9 ConSurf].
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1BD9 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BD9 OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:9782050</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Banfield, M J.]]
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[[Category: Large Structures]]
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[[Category: Barker, J J.]]
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[[Category: Banfield MJ]]
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[[Category: Brady, R L.]]
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[[Category: Barker JJ]]
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[[Category: Perry, A C.F.]]
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[[Category: Brady RL]]
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[[Category: Lipid-binding]]
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[[Category: Perry ACF]]
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[[Category: Signalling]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:43:09 2009''
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Current revision

HUMAN PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN

PDB ID 1bd9

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OCA

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