2ovo

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[[Image:2ovo.png|left|200px]]
 
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==THE CRYSTAL AND MOLECULAR STRUCTURE OF THE THIRD DOMAIN OF SILVER PHEASANT OVOMUCOID (OMSVP3)==
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The line below this paragraph, containing "STRUCTURE_2ovo", creates the "Structure Box" on the page.
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<StructureSection load='2ovo' size='340' side='right'caption='[[2ovo]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ovo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lophura_nycthemera Lophura nycthemera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OVO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ovo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ovo OCA], [https://pdbe.org/2ovo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ovo RCSB], [https://www.ebi.ac.uk/pdbsum/2ovo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ovo ProSAT]</span></td></tr>
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{{STRUCTURE_2ovo| PDB=2ovo | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IOVO_LOPNY IOVO_LOPNY]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ov/2ovo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ovo ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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OMSVP3 and OMTKY3 (third domains of silver pheasant and turkey ovomucoid inhibitor) are Kazal-type serine proteinase inhibitors. They have been isomorphously crystallized in the monoclinic space group C2 with cell dimensions of a = 4.429 nm, b = 2.115 nm, c = 4.405 nm, beta = 107 degrees. The asymmetric unit contains one molecule corresponding to an extremely low volume per unit molecular mass of 0.0017 nm3/Da. Data collection was only possible for the OMSVP3 crystals. Orientation and position of the OMSVP3 molecules in the monoclinic unit cells were determined using Patterson search methods and the known structure of the third domain of Japanese quail ovomucoid (OMJPQ3) [Papamokos, E., Weber, E., Bode, W., Huber, R., Empie, M. W., Kato, I. and Laskowski, M., Jr (1982) J. Mol. Biol. 158, 515-537]. The OMSVP3 structure has been refined by restrained crystallographic refinement yielding a final R value of 0.199 for data to 0.15 nm resolution. Conformation and hydrogen-bonding pattern of OMSVP3 and OMJPQ3 are very similar. Large deviations occur at the NH2 terminus owing to different crystal packing, and at the C terminus of the central helix, representing an intrinsic property and resulting from amino acid substitutions far away from this site. The deviation of OMSVP3 from OMTKY3 complexed with the Streptomyces griseus protease B is very small [Fujinaga, M., Read, R. J., Sielecki, A., Ardelt, W., Laskowski, M., Jr and James, M. N. G. (1982) Proc. Natl Acad. Sci. USA, 79, 4868-4872].
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===THE CRYSTAL AND MOLECULAR STRUCTURE OF THE THIRD DOMAIN OF SILVER PHEASANT OVOMUCOID (OMSVP3)===
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The crystal and molecular structure of the third domain of silver pheasant ovomucoid (OMSVP3).,Bode W, Epp O, Huber R, Laskowski M Jr, Ardelt W Eur J Biochem. 1985 Mar 1;147(2):387-95. PMID:3971987<ref>PMID:3971987</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2ovo" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Trypsin inhibitor 3D structures|Trypsin inhibitor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 3971987 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_3971987}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2OVO is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Lophura_nycthemera Lophura nycthemera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OVO OCA].
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==Reference==
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<ref group="xtra">PMID:3971987</ref><references group="xtra"/>
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[[Category: Lophura nycthemera]]
[[Category: Lophura nycthemera]]
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[[Category: Bode, W.]]
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[[Category: Bode W]]
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[[Category: Epp, O.]]
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[[Category: Epp O]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:45:28 2009''
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THE CRYSTAL AND MOLECULAR STRUCTURE OF THE THIRD DOMAIN OF SILVER PHEASANT OVOMUCOID (OMSVP3)

PDB ID 2ovo

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