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3dad

From Proteopedia

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{{Seed}}
 
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[[Image:3dad.png|left|200px]]
 
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==Crystal structure of the N-terminal regulatory domains of the formin FHOD1==
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The line below this paragraph, containing "STRUCTURE_3dad", creates the "Structure Box" on the page.
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<StructureSection load='3dad' size='340' side='right'caption='[[3dad]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3dad]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DAD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dad OCA], [https://pdbe.org/3dad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dad RCSB], [https://www.ebi.ac.uk/pdbsum/3dad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dad ProSAT]</span></td></tr>
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{{STRUCTURE_3dad| PDB=3dad | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of the N-terminal regulatory domains of the formin FHOD1===
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[https://www.uniprot.org/uniprot/FHOD1_HUMAN FHOD1_HUMAN] Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.<ref>PMID:14576350</ref> <ref>PMID:15878344</ref> <ref>PMID:18694941</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_18786395}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 18786395 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3dad_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_18786395}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dad ConSurf].
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3DAD is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAD OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:18786395</ref><ref group="xtra">PMID:17909294</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fackler, O T.]]
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[[Category: Large Structures]]
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[[Category: Geyer, M.]]
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[[Category: Fackler OT]]
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[[Category: Pylypenko, O.]]
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[[Category: Geyer M]]
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[[Category: Rak, A.]]
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[[Category: Pylypenko O]]
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[[Category: Schonichen, A.]]
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[[Category: Rak A]]
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[[Category: Schulte, A.]]
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[[Category: Schonichen A]]
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[[Category: Stolp, B.]]
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[[Category: Schulte A]]
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[[Category: Actin-binding]]
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[[Category: Stolp B]]
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[[Category: Armadillo repeat]]
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[[Category: Coiled coil]]
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[[Category: Cytoplasm]]
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[[Category: Cytoskeleton]]
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[[Category: Fhod1]]
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[[Category: Formin]]
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[[Category: Gtpase-binding domain]]
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[[Category: Phosphoprotein]]
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[[Category: Signaling protein]]
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[[Category: Ubiquitin-superfold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:46:37 2009''
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Current revision

Crystal structure of the N-terminal regulatory domains of the formin FHOD1

PDB ID 3dad

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