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1ncn

From Proteopedia

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{{Seed}}
 
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[[Image:1ncn.png|left|200px]]
 
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<!--
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==the receptor-binding domain of human B7-2==
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The line below this paragraph, containing "STRUCTURE_1ncn", creates the "Structure Box" on the page.
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<StructureSection load='1ncn' size='340' side='right'caption='[[1ncn]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ncn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NCN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ncn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ncn OCA], [https://pdbe.org/1ncn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ncn RCSB], [https://www.ebi.ac.uk/pdbsum/1ncn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ncn ProSAT]</span></td></tr>
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{{STRUCTURE_1ncn| PDB=1ncn | SCENE= }}
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</table>
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== Function ==
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===the receptor-binding domain of human B7-2===
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[https://www.uniprot.org/uniprot/CD86_HUMAN CD86_HUMAN] Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_12606712}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 12606712 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nc/1ncn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_12606712}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ncn ConSurf].
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1NCN is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCN OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:12606712</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Almo, S C.]]
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[[Category: Large Structures]]
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[[Category: Nathenson, S G.]]
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[[Category: Almo SC]]
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[[Category: Schwartz, J D.]]
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[[Category: Nathenson SG]]
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[[Category: Zhang, X.]]
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[[Category: Schwartz JD]]
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[[Category: Beta strand]]
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[[Category: Zhang X]]
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[[Category: Ig v]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:49:24 2009''
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Current revision

the receptor-binding domain of human B7-2

PDB ID 1ncn

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OCA

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