2o6r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:22, 30 October 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2o6r.png|left|200px]]
 
-
<!--
+
==Structural diversity of the hagfish Variable Lymphocyte Receptors B61==
-
The line below this paragraph, containing "STRUCTURE_2o6r", creates the "Structure Box" on the page.
+
<StructureSection load='2o6r' size='340' side='right'caption='[[2o6r]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2o6r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O6R FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o6r OCA], [https://pdbe.org/2o6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o6r RCSB], [https://www.ebi.ac.uk/pdbsum/2o6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o6r ProSAT]</span></td></tr>
-
{{STRUCTURE_2o6r| PDB=2o6r | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q4G1L2_EPTBU Q4G1L2_EPTBU]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o6/2o6r_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o6r ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Variable lymphocyte receptors (VLRs) are recently discovered leucine-rich repeat (LRR) family proteins that mediate adaptive immune responses in jawless fish. Phylogenetically it is the oldest adaptive immune receptor and the first one with a non-immunoglobulin fold. We present the crystal structures of one VLR-A and two VLR-B clones from the inshore hagfish. The hagfish VLRs have the characteristic horseshoe-shaped structure of LRR family proteins. The backbone structures of their LRR modules are highly homologous, and the sequence variation is concentrated on the concave surface of the protein. The conservation of key residues suggests that our structures are likely to represent the LRR structures of the entire repertoire of jawless fish VLRs. The analysis of sequence variability, prediction of protein interaction surfaces, amino acid composition analysis, and structural comparison with other LRR proteins suggest that the hypervariable concave surface is the most probable antigen binding site of the VLR.
-
===Structural diversity of the hagfish Variable Lymphocyte Receptors B61===
+
Structural diversity of the hagfish variable lymphocyte receptors.,Kim HM, Oh SC, Lim KJ, Kasamatsu J, Heo JY, Park BS, Lee H, Yoo OJ, Kasahara M, Lee JO J Biol Chem. 2007 Mar 2;282(9):6726-32. Epub 2006 Dec 27. PMID:17192264<ref>PMID:17192264</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2o6r" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_17192264}}, adds the Publication Abstract to the page
+
*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 17192264 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_17192264}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
2O6R is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O6R OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:17192264</ref><references group="xtra"/>
+
[[Category: Eptatretus burgeri]]
[[Category: Eptatretus burgeri]]
-
[[Category: Kim, H M.]]
+
[[Category: Large Structures]]
-
[[Category: Lee, J O.]]
+
[[Category: Kim HM]]
-
[[Category: Oh, S C.]]
+
[[Category: Lee JO]]
-
[[Category: Immune system]]
+
[[Category: Oh SC]]
-
[[Category: Leucine-rich repeat protein]]
+
-
[[Category: Lrr]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:55:16 2009''
+

Current revision

Structural diversity of the hagfish Variable Lymphocyte Receptors B61

PDB ID 2o6r

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2o6r"
Personal tools