This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ksq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:03, 3 April 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1ksq.png|left|200px]]
 
-
<!--
+
==NMR Study of the Third TB Domain from Latent Transforming Growth Factor-beta Binding Protein-1==
-
The line below this paragraph, containing "STRUCTURE_1ksq", creates the "Structure Box" on the page.
+
<StructureSection load='1ksq' size='340' side='right'caption='[[1ksq]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1ksq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KSQ FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ksq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ksq OCA], [https://pdbe.org/1ksq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ksq RCSB], [https://www.ebi.ac.uk/pdbsum/1ksq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ksq ProSAT]</span></td></tr>
-
{{STRUCTURE_1ksq| PDB=1ksq | SCENE= }}
+
</table>
-
 
+
== Disease ==
-
===NMR Study of the Third TB Domain from Latent Transforming Growth Factor-beta Binding Protein-1===
+
[https://www.uniprot.org/uniprot/LTBP1_HUMAN LTBP1_HUMAN] Autosomal recessive cutis laxa type 1. The disease is caused by variants affecting the gene represented in this entry.
-
 
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/LTBP1_HUMAN LTBP1_HUMAN] Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742).<ref>PMID:15184403</ref> <ref>PMID:2022183</ref> <ref>PMID:22278742</ref> <ref>PMID:8617200</ref> <ref>PMID:8939931</ref>
-
<!--
+
== Evolutionary Conservation ==
-
The line below this paragraph, {{ABSTRACT_PUBMED_14607119}}, adds the Publication Abstract to the page
+
[[Image:Consurf_key_small.gif|200px|right]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 14607119 is the PubMed ID number.
+
Check<jmol>
-
-->
+
<jmolCheckbox>
-
{{ABSTRACT_PUBMED_14607119}}
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ks/1ksq_consurf.spt"</scriptWhenChecked>
-
 
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
==About this Structure==
+
<text>to colour the structure by Evolutionary Conservation</text>
-
1KSQ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSQ OCA].
+
</jmolCheckbox>
-
 
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ksq ConSurf].
-
==Reference==
+
<div style="clear:both"></div>
-
<ref group="xtra">PMID:14607119</ref><references group="xtra"/>
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Downing, A K.]]
+
[[Category: Large Structures]]
-
[[Category: Handford, P A.]]
+
[[Category: Downing AK]]
-
[[Category: Knott, V.]]
+
[[Category: Handford PA]]
-
[[Category: Lack, J.]]
+
[[Category: Knott V]]
-
[[Category: Rifkin, D B.]]
+
[[Category: Lack J]]
-
[[Category: Yuan, X.]]
+
[[Category: O'leary JM]]
-
[[Category: Leary, J M.O.]]
+
[[Category: Rifkin DB]]
-
[[Category: Lap]]
+
[[Category: Yuan X]]
-
[[Category: Latency associated propeptide]]
+
-
[[Category: Latent transforming growth factor-beta binding protein-1]]
+
-
[[Category: Ltbp-1]]
+
-
[[Category: Nmr structure]]
+
-
[[Category: Tb domain]]
+
-
[[Category: Tgf-beta]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:56:45 2009''
+

Current revision

NMR Study of the Third TB Domain from Latent Transforming Growth Factor-beta Binding Protein-1

PDB ID 1ksq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ksq"
Personal tools