2izy

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{{Seed}}
 
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[[Image:2izy.png|left|200px]]
 
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==Molecular Basis of AKAP Specificity for PKA Regulatory Subunits==
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The line below this paragraph, containing "STRUCTURE_2izy", creates the "Structure Box" on the page.
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<StructureSection load='2izy' size='340' side='right'caption='[[2izy]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2izy]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IZY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2izy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2izy OCA], [https://pdbe.org/2izy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2izy RCSB], [https://www.ebi.ac.uk/pdbsum/2izy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2izy ProSAT]</span></td></tr>
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{{STRUCTURE_2izy| PDB=2izy | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAP2_MOUSE KAP2_MOUSE] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iz/2izy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2izy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Localization of cyclic AMP (cAMP)-dependent protein kinase (PKA) by A kinase-anchoring proteins (AKAPs) restricts the action of this broad specificity kinase. The high-resolution crystal structures of the docking and dimerization (D/D) domain of the RIIalpha regulatory subunit of PKA both in the apo state and in complex with the high-affinity anchoring peptide AKAP-IS explain the molecular basis for AKAP-regulatory subunit recognition. AKAP-IS folds into an amphipathic alpha helix that engages an essentially preformed shallow groove on the surface of the RII dimer D/D domains. Conserved AKAP aliphatic residues dominate interactions to RII at the predominantly hydrophobic interface, whereas polar residues are important in conferring R subunit isoform specificity. Using a peptide screening approach, we have developed SuperAKAP-IS, a peptide that is 10,000-fold more selective for the RII isoform relative to RI and can be used to assess the impact of PKA isoform-selective anchoring on cAMP-responsive events inside cells.
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===MOLECULAR BASIS OF AKAP SPECIFICITY FOR PKA REGULATORY SUBUNITS===
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Molecular basis of AKAP specificity for PKA regulatory subunits.,Gold MG, Lygren B, Dokurno P, Hoshi N, McConnachie G, Tasken K, Carlson CR, Scott JD, Barford D Mol Cell. 2006 Nov 3;24(3):383-95. PMID:17081989<ref>PMID:17081989</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2izy" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17081989}}, adds the Publication Abstract to the page
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*[[CAMP-dependent protein kinase 3D structures|CAMP-dependent protein kinase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17081989 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17081989}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2IZY is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZY OCA].
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==Reference==
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<ref group="xtra">PMID:17081989</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: CAMP-dependent protein kinase]]
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[[Category: Barford D]]
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[[Category: Barford, D.]]
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[[Category: Carlson CR]]
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[[Category: Carlson, C R.]]
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[[Category: Dokurno P]]
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[[Category: Dokurno, P.]]
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[[Category: Gold MG]]
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[[Category: Gold, M G.]]
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[[Category: Hoshi N]]
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[[Category: Hoshi, N.]]
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[[Category: Lygren B]]
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[[Category: Lygren, B.]]
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[[Category: McConnachie G]]
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[[Category: Mcconnachie, G.]]
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[[Category: Scott JD]]
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[[Category: Scott, J D.]]
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[[Category: Tasken K]]
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[[Category: Tasken, K.]]
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[[Category: Acetylation]]
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[[Category: Camp]]
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[[Category: Camp-binding]]
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[[Category: D/d]]
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[[Category: Kinase]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphorylation]]
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[[Category: Pka]]
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[[Category: Rii]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:02:12 2009''
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Current revision

Molecular Basis of AKAP Specificity for PKA Regulatory Subunits

PDB ID 2izy

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