1qwi

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{{Seed}}
 
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[[Image:1qwi.png|left|200px]]
 
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==Crystal Structure of E. coli OsmC==
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The line below this paragraph, containing "STRUCTURE_1qwi", creates the "Structure Box" on the page.
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<StructureSection load='1qwi' size='340' side='right'caption='[[1qwi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qwi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QWI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1qwi| PDB=1qwi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qwi OCA], [https://pdbe.org/1qwi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qwi RCSB], [https://www.ebi.ac.uk/pdbsum/1qwi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qwi ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qw/1qwi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qwi ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The osmotically inducible protein OsmC, like its better-characterized homolog, the organic hydroperoxide protein Ohr, is involved in defense against oxidative stress caused by exposure to organic hydroperoxides. The crystal structure of Escherichia coli OsmC reported here reveals that the protein is a tightly folded domain-swapped dimer with two active sites located at the monomer interface on opposite sides of the molecule. We demonstrate that OsmC preferentially metabolizes organic hydroperoxides over inorganic hydrogen peroxide. On the basis of structural and enzymatic similarities, we propose that the OsmC catalytic mechanism is analogous to that of the Ohr proteins and of the structurally unrelated peroxiredoxins, directly using highly reactive cysteine thiol groups to elicit hydroperoxide reduction.
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===Crystal Structure of E. coli OsmC===
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Structural and functional features of the Escherichia coli hydroperoxide resistance protein OsmC.,Lesniak J, Barton WA, Nikolov DB Protein Sci. 2003 Dec;12(12):2838-43. PMID:14627744<ref>PMID:14627744</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_14627744}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1qwi" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 14627744 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14627744}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1QWI is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QWI OCA].
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==Reference==
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<ref group="xtra">PMID:14627744</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Barton, W A.]]
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[[Category: Large Structures]]
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[[Category: Lesniak, J.]]
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[[Category: Barton WA]]
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[[Category: Nikolov, D B.]]
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[[Category: Lesniak J]]
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[[Category: Hydroperoxide resistance]]
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[[Category: Nikolov DB]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:09:24 2009''
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Current revision

Crystal Structure of E. coli OsmC

PDB ID 1qwi

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