3bz5

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{{Seed}}
 
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[[Image:3bz5.png|left|200px]]
 
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==Functional domain of InlJ from Listeria monocytogenes includes a cysteine ladder==
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The line below this paragraph, containing "STRUCTURE_3bz5", creates the "Structure Box" on the page.
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<StructureSection load='3bz5' size='340' side='right'caption='[[3bz5]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes_EGD-e Listeria monocytogenes EGD-e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BZ5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3bz5| PDB=3bz5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bz5 OCA], [https://pdbe.org/3bz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bz5 RCSB], [https://www.ebi.ac.uk/pdbsum/3bz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bz5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/INLJ_LISMO INLJ_LISMO] Involved in several steps of L.monocytogenes infection.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bz/3bz5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bz5 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report on the crystal structure of the internalin domain of InlJ, a virulence-associated surface protein of Listeria monocytogenes, at 2.7-A resolution. InlJ is a member of the internalin family of listerial cell surface proteins characterized by a common N-terminal domain. InlJ bears 15 leucine-rich repeats (LRRs), the same number as in InlA, the prototypical internalin family member. The LRRs of InlJ differ from those of other internalins by having 21, rather than 22, residues and by replacing 1 LRR-defining hydrophobic residue with a conserved cysteine. These cysteines stack to form an intramolecular ladder and regular hydrophobic interactions in consecutive repeats. Analyzing the curvature, twist, and lateral bending angles of InlJ and comparing these with several other LRR proteins, we provide a systematic geometric comparison of LRR protein structures (http://bragi2.helmholtz-hzi.de/Angulator/). These indicate that both cysteine and asparagine ladders stabilize the LRR fold, whereas substitutions in some repeat positions are more likely than others to induce changes in LRR geometry.
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===Functional domain of InlJ from Listeria monocytogenes includes a cysteine ladder===
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Crystal structure and standardized geometric analysis of InlJ, a listerial virulence factor and leucine-rich repeat protein with a novel cysteine ladder.,Bublitz M, Holland C, Sabet C, Reichelt J, Cossart P, Heinz DW, Bierne H, Schubert WD J Mol Biol. 2008 Apr 18;378(1):87-96. Epub 2008 Feb 20. PMID:18343406<ref>PMID:18343406</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<!--
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18343406}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3bz5" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18343406 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18343406}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3BZ5 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BZ5 OCA].
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[[Category: Listeria monocytogenes EGD-e]]
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[[Category: Bierne H]]
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==Reference==
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[[Category: Bublitz M]]
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<ref group="xtra">PMID:18343406</ref><references group="xtra"/>
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[[Category: Cossart P]]
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[[Category: Listeria monocytogenes]]
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[[Category: Heinz DW]]
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[[Category: Bierne, H.]]
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[[Category: Holland C]]
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[[Category: Bublitz, M.]]
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[[Category: Reichelt J]]
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[[Category: Cossart, P.]]
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[[Category: Sabet C]]
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[[Category: Heinz, D W.]]
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[[Category: Schubert WD]]
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[[Category: Holland, C.]]
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[[Category: Reichelt, J.]]
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[[Category: Sabet, C.]]
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[[Category: Schubert, W D.]]
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[[Category: Asparagine ladder]]
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[[Category: Cell adhesion]]
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[[Category: Cell wall]]
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[[Category: Cysteine ladder]]
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[[Category: Internalin]]
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[[Category: Leucine-rich repeat]]
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[[Category: Peptidoglycan-anchor]]
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[[Category: Secreted]]
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[[Category: Solenoid]]
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[[Category: Virulence factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:27:14 2009''
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Current revision

Functional domain of InlJ from Listeria monocytogenes includes a cysteine ladder

PDB ID 3bz5

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