1tr8

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{{Seed}}
 
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[[Image:1tr8.png|left|200px]]
 
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==Crystal Structure of archaeal Nascent Polypeptide-associated Complex (aeNAC)==
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The line below this paragraph, containing "STRUCTURE_1tr8", creates the "Structure Box" on the page.
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<StructureSection load='1tr8' size='340' side='right'caption='[[1tr8]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tr8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_marburgensis Methanothermobacter marburgensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TR8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1tr8| PDB=1tr8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tr8 OCA], [https://pdbe.org/1tr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tr8 RCSB], [https://www.ebi.ac.uk/pdbsum/1tr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tr8 ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tr/1tr8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tr8 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Nascent polypeptide-associated complex (NAC) was identified in eukaryotes as the first cytosolic factor that contacts the nascent polypeptide chain emerging from the ribosome. NAC is highly conserved from yeast to humans. Mutations in NAC cause severe embryonically lethal phenotypes in mice, Drosophila, and Caenorhabditis elegans. NAC was suggested to protect the nascent chain from inappropriate early interactions with cytosolic factors. Eukaryotic NAC is a heterodimer with two subunits sharing substantial homology with each other. All sequenced archaebacterial genomes exhibit only one gene homologous to the NAC subunits. Here we present the first archaebacterial NAC homolog. It forms a homodimer, and as eukaryotic NAC it is associated with ribosomes and contacts the emerging nascent chain on the ribosome. We present the first crystal structure of a NAC protein revealing two structural features: (i) a novel unique protein fold that mediates dimerization of the complex, and (ii) a ubiquitin-associated domain that suggests a yet unidentified role for NAC in the cellular protein quality control system via the ubiquitination pathway. Based on the presented structure we propose a model for the eukaryotic heterodimeric NAC domain.
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===Crystal Structure of archaeal Nascent Polypeptide-associated Complex (aeNAC)===
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The crystal structure of archaeal nascent polypeptide-associated complex (NAC) reveals a unique fold and the presence of a ubiquitin-associated domain.,Spreter T, Pech M, Beatrix B J Biol Chem. 2005 Apr 22;280(16):15849-54. Epub 2005 Jan 22. PMID:15665334<ref>PMID:15665334</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15665334}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1tr8" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15665334 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15665334}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1TR8 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Methanothermobacter_marburgensis Methanothermobacter marburgensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TR8 OCA].
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==Reference==
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<ref group="xtra">PMID:15665334</ref><references group="xtra"/>
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[[Category: Methanothermobacter marburgensis]]
[[Category: Methanothermobacter marburgensis]]
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[[Category: Beatrix, B.]]
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[[Category: Beatrix B]]
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[[Category: Pech, M.]]
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[[Category: Pech M]]
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[[Category: Spreter, T.]]
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[[Category: Spreter T]]
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[[Category: Chaperone]]
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[[Category: Nascent polypeptide-associated complex]]
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[[Category: Ribosome]]
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[[Category: Uba-domain]]
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[[Category: Ubiquitin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:31:04 2009''
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Current revision

Crystal Structure of archaeal Nascent Polypeptide-associated Complex (aeNAC)

PDB ID 1tr8

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