1fio

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{{Seed}}
 
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[[Image:1fio.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF YEAST T-SNARE PROTEIN SSO1==
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The line below this paragraph, containing "STRUCTURE_1fio", creates the "Structure Box" on the page.
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<StructureSection load='1fio' size='340' side='right'caption='[[1fio]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fio]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FIO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1fio| PDB=1fio | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fio OCA], [https://pdbe.org/1fio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fio RCSB], [https://www.ebi.ac.uk/pdbsum/1fio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fio ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SSO1_YEAST SSO1_YEAST] Required for vesicle fusion with the plasma membrane.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fi/1fio_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fio ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In the eukaryotic secretory and endocytic pathways, transport vesicles shuttle cargo among intracellular organelles and to and from the plasma membrane. Cargo delivery entails fusion of the transport vesicle with its target, a process thought to be mediated by membrane bridging SNARE protein complexes. Temporal and spatial control of intracellular trafficking depends in part on regulating the assembly of these complexes. In vitro, SNARE assembly is inhibited by the closed conformation adopted by the syntaxin family of SNAREs. To visualize this closed conformation directly, the X-ray crystal structure of a yeast syntaxin, Sso1p, has been determined and refined to 2.1 A resolution. Mutants designed to destabilize the closed conformation exhibit accelerated rates of SNARE assembly. Our results provide insight into the mechanism of SNARE assembly and its intramolecular and intermolecular regulation.
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===CRYSTAL STRUCTURE OF YEAST T-SNARE PROTEIN SSO1===
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Interactions within the yeast t-SNARE Sso1p that control SNARE complex assembly.,Munson M, Chen X, Cocina AE, Schultz SM, Hughson FM Nat Struct Biol. 2000 Oct;7(10):894-902. PMID:11017200<ref>PMID:11017200</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11017200}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1fio" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11017200 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11017200}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1FIO is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FIO OCA].
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==Reference==
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<ref group="xtra">PMID:11017200</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Chen, X.]]
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[[Category: Chen X]]
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[[Category: Cocina, A E.]]
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[[Category: Cocina AE]]
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[[Category: Hughson, F M.]]
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[[Category: Hughson FM]]
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[[Category: Munson, M.]]
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[[Category: Munson M]]
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[[Category: Schultz, S M.]]
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[[Category: Schultz SM]]
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[[Category: Alpha helix]]
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[[Category: Four helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:31:54 2009''
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Current revision

CRYSTAL STRUCTURE OF YEAST T-SNARE PROTEIN SSO1

PDB ID 1fio

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