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1gcu

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{{Seed}}
 
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[[Image:1gcu.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF RAT BILIVERDIN REDUCTASE AT 1.4 A==
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The line below this paragraph, containing "STRUCTURE_1gcu", creates the "Structure Box" on the page.
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<StructureSection load='1gcu' size='340' side='right'caption='[[1gcu]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gcu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GCU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GCU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gcu OCA], [https://pdbe.org/1gcu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gcu RCSB], [https://www.ebi.ac.uk/pdbsum/1gcu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gcu ProSAT]</span></td></tr>
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{{STRUCTURE_1gcu| PDB=1gcu | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BIEA_RAT BIEA_RAT] Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gc/1gcu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gcu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Biliverdin reductase (BVR) is a soluble cytoplasmic enzyme that catalyzes the conversion of biliverdin to bilirubin using NADH or NADPH as electron donor. Bilirubin is a significant biological antioxidant, but it is also neurotoxic and the cause of kernicterus. In this study, we have determined the crystal structure of rat BVR at 1.4 A resolution. The structure contains two domains: an N-terminal domain characteristic of a dinucleotide binding fold (Rossmann fold) and a C-terminal domain that is predominantly an antiparallel six-stranded beta-sheet. Based on this structure, we propose modes of binding for NAD(P)H and biliverdin, and a possible mechanism for the enzyme.
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===CRYSTAL STRUCTURE OF RAT BILIVERDIN REDUCTASE AT 1.4 A===
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Crystal structure of rat biliverdin reductase.,Kikuchi A, Park SY, Miyatake H, Sun D, Sato M, Yoshida T, Shiro Y Nat Struct Biol. 2001 Mar;8(3):221-5. PMID:11224565<ref>PMID:11224565</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11224565}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1gcu" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11224565 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11224565}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1GCU is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GCU OCA].
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==Reference==
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<ref group="xtra">PMID:11224565</ref><references group="xtra"/>
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[[Category: Biliverdin reductase]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Kikuchi, A.]]
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[[Category: Kikuchi A]]
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[[Category: Park, S Y.]]
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[[Category: Park SY]]
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[[Category: Shiro, Y.]]
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[[Category: Shiro Y]]
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[[Category: Biliverdin]]
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[[Category: Rossmann fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:38:44 2009''
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Current revision

CRYSTAL STRUCTURE OF RAT BILIVERDIN REDUCTASE AT 1.4 A

PDB ID 1gcu

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