1q68

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{{Seed}}
 
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[[Image:1q68.png|left|200px]]
 
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==Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments==
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The line below this paragraph, containing "STRUCTURE_1q68", creates the "Structure Box" on the page.
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<StructureSection load='1q68' size='340' side='right'caption='[[1q68]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1q68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q68 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1q68| PDB=1q68 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q68 OCA], [https://pdbe.org/1q68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q68 RCSB], [https://www.ebi.ac.uk/pdbsum/1q68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q68 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CD4_HUMAN CD4_HUMAN] Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q6/1q68_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q68 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The T cell coreceptors CD4 and CD8 both associate via their cytoplasmic tails with the N-terminus of the Src-family tyrosine kinase Lck. These interactions require zinc and are critical for T cell development and activation. We examined the folding and solution structures of ternary CD4-Lck-Zn2+ and CD8alpha-Lck-Zn2+ complexes. The coreceptor tails and the Lck N-terminus are unstructured in isolation but assemble in the presence of zinc to form compactly folded heterodimeric domains. The cofolded complexes have similar "zinc clasp" cores that are augmented by distinct structural elements. A dileucine motif required for clathrin-mediated endocytosis of CD4 is masked by Lck.
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===Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments===
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A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.,Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ Science. 2003 Sep 19;301(5640):1725-8. PMID:14500983<ref>PMID:14500983</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1q68" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_14500983}}, adds the Publication Abstract to the page
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*[[CD4 3D structures|CD4 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14500983 is the PubMed ID number.
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*[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_14500983}}
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<references/>
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__TOC__
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==Disease==
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</StructureSection>
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Known disease associated with this structure: CD4 lymphocyte deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186940 186940]], Lupus erythematosus, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186940 186940]], SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]]
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==About this Structure==
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1Q68 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q68 OCA].
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==Reference==
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<ref group="xtra">PMID:14500983</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Blacklow, S C.]]
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[[Category: Large Structures]]
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[[Category: Eck, M J.]]
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[[Category: Blacklow SC]]
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[[Category: Kim, P W.]]
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[[Category: Eck MJ]]
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[[Category: Sun, Z Y.]]
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[[Category: Kim PW]]
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[[Category: Wagner, G.]]
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[[Category: Sun ZY]]
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[[Category: Beta hairpin]]
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[[Category: Wagner G]]
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[[Category: Helix-helix interaction]]
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[[Category: Peptide-peptide complex]]
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[[Category: Zinc coordination]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:40:47 2009''
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Current revision

Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments

PDB ID 1q68

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OCA

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