1xwv

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{{Seed}}
 
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[[Image:1xwv.png|left|200px]]
 
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==Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity==
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The line below this paragraph, containing "STRUCTURE_1xwv", creates the "Structure Box" on the page.
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<StructureSection load='1xwv' size='340' side='right'caption='[[1xwv]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xwv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dermatophagoides_farinae Dermatophagoides farinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XWV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PE3:3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL'>PE3</scene>, <scene name='pdbligand=XPE:3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL'>XPE</scene></td></tr>
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{{STRUCTURE_1xwv| PDB=1xwv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xwv OCA], [https://pdbe.org/1xwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xwv RCSB], [https://www.ebi.ac.uk/pdbsum/1xwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xwv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALL2_DERFA ALL2_DERFA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xw/1xwv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xwv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The X-ray structure of the group 2 major allergen from Dermatophagoides farinae (Der f 2) was determined to 1.83 A resolution. The overall Der f 2 structure comprises a single domain of immunoglobulin fold with two anti-parallel beta-sheets. A large hydrophobic cavity is formed in the interior of Der f 2. Structural comparisons to distantly related proteins suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes.
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===Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity===
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Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity.,Johannessen BR, Skov LK, Kastrup JS, Kristensen O, Bolwig C, Larsen JN, Spangfort M, Lund K, Gajhede M FEBS Lett. 2005 Feb 14;579(5):1208-12. Epub 2005 Jan 21. PMID:15710415<ref>PMID:15710415</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15710415}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1xwv" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15710415 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15710415}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1XWV is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Dermatophagoides_farinae Dermatophagoides farinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWV OCA].
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==Reference==
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<ref group="xtra">PMID:15710415</ref><references group="xtra"/>
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[[Category: Dermatophagoides farinae]]
[[Category: Dermatophagoides farinae]]
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[[Category: Bolwig, C.]]
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[[Category: Large Structures]]
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[[Category: Gajhede, M.]]
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[[Category: Bolwig C]]
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[[Category: Johannessen, B R.]]
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[[Category: Gajhede M]]
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[[Category: Kastrup, J S.]]
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[[Category: Johannessen BR]]
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[[Category: Kristensen, O.]]
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[[Category: Kastrup JS]]
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[[Category: Larsen, J N.]]
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[[Category: Kristensen O]]
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[[Category: Lund, K.]]
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[[Category: Larsen JN]]
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[[Category: Skov, L K.]]
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[[Category: Lund K]]
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[[Category: Spangfort, M.]]
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[[Category: Skov LK]]
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[[Category: Beta sheet]]
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[[Category: Spangfort M]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:47:00 2009''
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Current revision

Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity

PDB ID 1xwv

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