2j43

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{{Seed}}
 
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[[Image:2j43.png|left|200px]]
 
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==Alpha-glucan recognition by family 41 carbohydrate-binding modules from streptococcal virulence factors==
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The line below this paragraph, containing "STRUCTURE_2j43", creates the "Structure Box" on the page.
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<StructureSection load='2j43' size='340' side='right'caption='[[2j43]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2j43]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J43 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_2j43| PDB=2j43 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j43 OCA], [https://pdbe.org/2j43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j43 RCSB], [https://www.ebi.ac.uk/pdbsum/2j43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j43 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8KLP1_STRPY Q8KLP1_STRPY]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j4/2j43_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j43 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The ability of pathogenic bacteria to recognize host glycans is often essential to their virulence. Here we report structure-function studies of previously uncharacterized glycogen-binding modules in the surface-anchored pullulanases from Streptococcus pneumoniae (SpuA) and Streptococcus pyogenes (PulA). Multivalent binding to glycogen leads to a strong interaction with alveolar type II cells in mouse lung tissue. X-ray crystal structures of the binding modules reveal a novel fusion of tandem modules into single, bivalent functional domains. In addition to indicating a structural basis for multivalent attachment, the structure of the SpuA modules in complex with carbohydrate provides insight into the molecular basis for glycogen specificity. This report provides the first evidence that intracellular lung glycogen may be a novel target of pathogenic streptococci and thus provides a rationale for the identification of the streptococcal alpha-glucan-metabolizing machinery as virulence factors.
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===ALPHA-GLUCAN RECOGNITION BY FAMILY 41 CARBOHYDRATE-BINDING MODULES FROM STREPTOCOCCAL VIRULENCE FACTORS===
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Identification and structural basis of binding to host lung glycogen by streptococcal virulence factors.,van Bueren AL, Higgins M, Wang D, Burke RD, Boraston AB Nat Struct Mol Biol. 2007 Jan;14(1):76-84. Epub 2006 Dec 24. PMID:17187076<ref>PMID:17187076</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17187076}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2j43" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17187076 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17187076}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2J43 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J43 OCA].
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==Reference==
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<ref group="xtra">PMID:17187076</ref><references group="xtra"/>
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[[Category: Streptococcus pyogenes]]
[[Category: Streptococcus pyogenes]]
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[[Category: Boraston, A B.]]
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[[Category: Boraston AB]]
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[[Category: Bueren, A Lammerts Van.]]
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[[Category: Burke RD]]
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[[Category: Burke, R D.]]
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[[Category: Higgins M]]
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[[Category: Higgins, M.]]
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[[Category: Lammerts van Bueren A]]
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[[Category: Wang, D.]]
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[[Category: Wang D]]
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[[Category: Carbohydrate-binding module]]
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[[Category: Family 41]]
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[[Category: Glycogen binding]]
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[[Category: Glycoside hydrolase]]
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[[Category: Pullulanase]]
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[[Category: Streptococcal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:50:30 2009''
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Current revision

Alpha-glucan recognition by family 41 carbohydrate-binding modules from streptococcal virulence factors

PDB ID 2j43

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