1ete

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{{Seed}}
 
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[[Image:1ete.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE FLT3 LIGAND==
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The line below this paragraph, containing "STRUCTURE_1ete", creates the "Structure Box" on the page.
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<StructureSection load='1ete' size='340' side='right'caption='[[1ete]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ete]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ETE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ETE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1ete| PDB=1ete | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ete FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ete OCA], [https://pdbe.org/1ete PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ete RCSB], [https://www.ebi.ac.uk/pdbsum/1ete PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ete ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FLT3L_HUMAN FLT3L_HUMAN] Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/et/1ete_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ete ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human Flt3 ligand (Flt3L) stimulates early hematopoiesis by activating a type III tyrosine kinase receptor on primitive bone marrow stem cells. The crystal structure of soluble Flt3L reveals that it is a homodimer of two short chain alpha-helical bundles. Comparisons of structure-function relationships of Flt3L with the homologous hematopoietic cytokines macrophage colony stimulating factor (MCSF) and stem cell factor (SCF) suggest that they have a common receptor binding mode that is distinct from the paradigm derived from the complex of growth hormone with its receptor. Furthermore, we identify recognition features common to all helical and cystine-knot protein ligands that activate type III tyrosine kinase receptors, and the closely related type V tyrosine kinase receptors.
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===CRYSTAL STRUCTURE OF THE FLT3 LIGAND===
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Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots.,Savvides SN, Boone T, Andrew Karplus P Nat Struct Biol. 2000 Jun;7(6):486-91. PMID:10881197<ref>PMID:10881197</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_10881197}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1ete" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10881197 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10881197}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1ETE is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ETE OCA].
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==Reference==
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<ref group="xtra">PMID:10881197</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Boone, T.]]
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[[Category: Large Structures]]
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[[Category: Karplus, P A.]]
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[[Category: Boone T]]
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[[Category: Savvides, S N.]]
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[[Category: Karplus PA]]
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[[Category: Four-helix bundle]]
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[[Category: Savvides SN]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:00:02 2009''
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Current revision

CRYSTAL STRUCTURE OF THE FLT3 LIGAND

PDB ID 1ete

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