2dzd

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{{Seed}}
 
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[[Image:2dzd.png|left|200px]]
 
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==Crystal structure of the biotin carboxylase domain of pyruvate carboxylase==
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The line below this paragraph, containing "STRUCTURE_2dzd", creates the "Structure Box" on the page.
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<StructureSection load='2dzd' size='340' side='right'caption='[[2dzd]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2dzd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_thermodenitrificans Geobacillus thermodenitrificans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DZD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dzd OCA], [https://pdbe.org/2dzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dzd RCSB], [https://www.ebi.ac.uk/pdbsum/2dzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dzd ProSAT]</span></td></tr>
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{{STRUCTURE_2dzd| PDB=2dzd | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q05FZ3_GEOTD Q05FZ3_GEOTD]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dz/2dzd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dzd ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The biotin carboxylase (BC) domain of pyruvate carboxylase (PC) from Bacillus thermodenitrificans (BC-bPC) was crystallized in an orthorhombic form (space group P2(1)2(1)2(1)), with unit-cell parameters a = 79.6, b = 116.0, c = 115.7 A. Two BC protomers are contained in the asymmetric unit. Diffraction data were collected at 100 K and the crystal structure was solved by the molecular-replacement method and refined against reflections in the 20.0-2.4 A resolution range, giving an R factor of 0.235 and a free R factor of 0.292. The overall structure of BC-bPC is similar to those of the BC subunits of Aquifex aeolicus PC (BC-aPC) and Escherichia coli ACC (BC-eACC). The crystal structure revealed that BC-bPC forms a unique dimeric quaternary structure, which might be caused as a result of the division of the BC domain from the rest of the protein. The position of domain B in BC-bPC differs from those in other enzymes of similar structure (BC-aPC and BC-eACC).
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===Crystal structure of the biotin carboxylase domain of pyruvate carboxylase===
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Structure of the biotin carboxylase domain of pyruvate carboxylase from Bacillus thermodenitrificans.,Kondo S, Nakajima Y, Sugio S, Sueda S, Islam MN, Kondo H Acta Crystallogr D Biol Crystallogr. 2007 Aug;63(Pt 8):885-90. Epub 2007, Jul 17. PMID:17642515<ref>PMID:17642515</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2dzd" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17642515}}, adds the Publication Abstract to the page
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*[[Pyruvate carboxylase 3D structures|Pyruvate carboxylase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17642515 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17642515}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2DZD is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Geobacillus_thermodenitrificans Geobacillus thermodenitrificans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZD OCA].
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==Reference==
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<ref group="xtra">PMID:17642515</ref><references group="xtra"/>
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[[Category: Geobacillus thermodenitrificans]]
[[Category: Geobacillus thermodenitrificans]]
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[[Category: Pyruvate carboxylase]]
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[[Category: Large Structures]]
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[[Category: Islam, M N.]]
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[[Category: Islam MN]]
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[[Category: Kondo, H.]]
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[[Category: Kondo H]]
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[[Category: Kondo, S.]]
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[[Category: Kondo S]]
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[[Category: Nakajima, Y.]]
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[[Category: Nakajima Y]]
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[[Category: Sueda, S.]]
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[[Category: Sueda S]]
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[[Category: Sugio, S.]]
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[[Category: Sugio S]]
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[[Category: Bacillus thermodenitrifican]]
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[[Category: Biotin carboxylase]]
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[[Category: Ligase]]
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[[Category: Pyruvate carboxylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:00:54 2009''
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Current revision

Crystal structure of the biotin carboxylase domain of pyruvate carboxylase

PDB ID 2dzd

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