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1pk1

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{{Seed}}
 
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[[Image:1pk1.png|left|200px]]
 
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<!--
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==Hetero SAM domain structure of Ph and Scm.==
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The line below this paragraph, containing "STRUCTURE_1pk1", creates the "Structure Box" on the page.
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<StructureSection load='1pk1' size='340' side='right'caption='[[1pk1]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pk1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PK1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PK1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1pk1| PDB=1pk1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pk1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pk1 OCA], [https://pdbe.org/1pk1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pk1 RCSB], [https://www.ebi.ac.uk/pdbsum/1pk1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pk1 ProSAT]</span></td></tr>
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</table>
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===Hetero SAM domain structure of Ph and Scm.===
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== Function ==
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[https://www.uniprot.org/uniprot/PHP_DROME PHP_DROME] Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Plays a role in regulating the expression of other pair-rule genes such as eve, ftz, and H.<ref>PMID:1346609</ref>
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_15905166}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15905166 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pk/1pk1_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15905166}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1PK1 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PK1 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pk1 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:15905166</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Bowie, J U.]]
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[[Category: Large Structures]]
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[[Category: Cascio, D.]]
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[[Category: Bowie JU]]
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[[Category: Kim, C A.]]
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[[Category: Cascio D]]
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[[Category: Kim, W.]]
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[[Category: Kim CA]]
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[[Category: Sawaya, M R.]]
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[[Category: Kim W]]
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[[Category: Hetero sam domain]]
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[[Category: Sawaya MR]]
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[[Category: Polymer]]
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[[Category: Transcriptional repression]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:02:43 2009''
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Current revision

Hetero SAM domain structure of Ph and Scm.

PDB ID 1pk1

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