2f9z

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{{Seed}}
 
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[[Image:2f9z.png|left|200px]]
 
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==Complex between the chemotaxis deamidase CheD and the chemotaxis phosphatase CheC from Thermotoga maritima==
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The line below this paragraph, containing "STRUCTURE_2f9z", creates the "Structure Box" on the page.
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<StructureSection load='2f9z' size='340' side='right'caption='[[2f9z]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2f9z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F9Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f9z OCA], [https://pdbe.org/2f9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f9z RCSB], [https://www.ebi.ac.uk/pdbsum/2f9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f9z ProSAT]</span></td></tr>
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{{STRUCTURE_2f9z| PDB=2f9z | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CHEC_THEMA CHEC_THEMA] Involved in restoring normal CheY-P levels by dephosphorylating CheY-P. Inhibits CheD by incorporating in its fold a structural motif that mimics a CheD substrate recognition site to bait and inactivate it.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/2f9z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f9z ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Signal transduction underlying bacterial chemotaxis involves excitatory phosphorylation and feedback control through deamidation and methylation of sensory receptors. The structure of a complex between the signal-terminating phosphatase, CheC, and the receptor-modifying deamidase, CheD, reveals how CheC mimics receptor substrates to inhibit CheD and how CheD stimulates CheC phosphatase activity. CheD resembles other cysteine deamidases from bacterial pathogens that inactivate host Rho-GTPases. CheD not only deamidates receptor glutamine residues contained within a conserved structural motif but also hydrolyzes glutamyl-methyl-esters at select regulatory positions. Substituting Gln into the receptor motif of CheC turns the inhibitor into a CheD substrate. Phospho-CheY, the intracellular signal and CheC target, stabilizes the CheC:CheD complex and reduces availability of CheD. A point mutation that dissociates CheC from CheD impairs chemotaxis in vivo. Thus, CheC incorporates an element of an upstream receptor to influence both its own effect on receptor output and that of its binding partner, CheD.
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===Complex between the chemotaxis deamidase CheD and the chemotaxis phosphatase CheC from Thermotoga maritima===
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A receptor-modifying deamidase in complex with a signaling phosphatase reveals reciprocal regulation.,Chao X, Muff TJ, Park SY, Zhang S, Pollard AM, Ordal GW, Bilwes AM, Crane BR Cell. 2006 Feb 10;124(3):561-71. PMID:16469702<ref>PMID:16469702</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2f9z" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16469702}}, adds the Publication Abstract to the page
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*[[Chemotaxis protein 3D structures|Chemotaxis protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16469702 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16469702}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2F9Z is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermotoga_maritima_msb8 Thermotoga maritima msb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9Z OCA].
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[[Category: Thermotoga maritima MSB8]]
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[[Category: Bilwes AM]]
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==Reference==
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[[Category: Chao X]]
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<ref group="xtra">PMID:16469702</ref><references group="xtra"/>
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[[Category: Crane BR]]
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[[Category: Thermotoga maritima msb8]]
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[[Category: Park SY]]
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[[Category: Bilwes, A M.]]
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[[Category: Chao, X.]]
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[[Category: Crane, B R.]]
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[[Category: Park, S Y]]
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[[Category: Aspartyl phosphatase]]
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[[Category: Bacterial chemotaxis]]
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[[Category: Protein complex]]
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[[Category: Receptor deamidase]]
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[[Category: Reciprocal regulation]]
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[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:03:24 2009''
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Current revision

Complex between the chemotaxis deamidase CheD and the chemotaxis phosphatase CheC from Thermotoga maritima

PDB ID 2f9z

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