1tve

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{{Seed}}
 
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[[Image:1tve.png|left|200px]]
 
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==Homoserine Dehydrogenase in complex with 4-(4-hydroxy-3-isopropylphenylthio)-2-isopropylphenol==
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The line below this paragraph, containing "STRUCTURE_1tve", creates the "Structure Box" on the page.
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<StructureSection load='1tve' size='340' side='right'caption='[[1tve]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tve]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TVE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=178:4-(4-HYDROXY-3-ISOPROPYLPHENYLTHIO)-2-ISOPROPYLPHENOL'>178</scene></td></tr>
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{{STRUCTURE_1tve| PDB=1tve | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tve OCA], [https://pdbe.org/1tve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tve RCSB], [https://www.ebi.ac.uk/pdbsum/1tve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tve ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DHOM_YEAST DHOM_YEAST]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tv/1tve_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tve ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A relatively unexploited potential target for antimicrobial agents is the biosynthesis of essential amino acids. Homoserine dehydrogenase, which reduces aspartate semi-aldehyde to homoserine in a NAD(P)H-dependent reaction, is one such target that is required for the biosynthesis of Met, Thr, and Ile from Asp. We report a small molecule screen of yeast homoserine dehydrogenase that has identified a new class of phenolic inhibitors of this class of enzyme. X-ray crystal structural analysis of one of the inhibitors in complex with homoserine dehydrogenase reveals that these molecules bind in the amino acid binding region of the active site and that the phenolic hydroxyl group interacts specifically with the backbone amide of Gly175. These results provide the first nonamino acid inhibitors of this class of enzyme and have the potential to be exploited as leads in antifungal compound design.
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===Homoserine Dehydrogenase in complex with 4-(4-hydroxy-3-isopropylphenylthio)-2-isopropylphenol===
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New phenolic inhibitors of yeast homoserine dehydrogenase.,Ejim L, Mirza IA, Capone C, Nazi I, Jenkins S, Chee GL, Berghuis AM, Wright GD Bioorg Med Chem. 2004 Jul 15;12(14):3825-30. PMID:15210149<ref>PMID:15210149</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15210149}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1tve" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15210149 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15210149}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1TVE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TVE OCA].
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==Reference==
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<ref group="xtra">PMID:15210149</ref><references group="xtra"/>
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[[Category: Homoserine dehydrogenase]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Berghuis, A M.]]
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[[Category: Berghuis AM]]
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[[Category: Capone, C.]]
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[[Category: Capone C]]
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[[Category: Chee, G L.]]
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[[Category: Chee GL]]
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[[Category: Ejim, L.]]
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[[Category: Ejim L]]
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[[Category: Jenkins, S.]]
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[[Category: Jenkins S]]
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[[Category: Mirza, I A.]]
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[[Category: Mirza IA]]
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[[Category: Nazi, I.]]
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[[Category: Nazi I]]
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[[Category: Wright, G D.]]
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[[Category: Wright GD]]
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[[Category: Amino acid biosynthesis]]
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[[Category: Antifungal]]
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[[Category: Small molecule screening]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:07:23 2009''
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Current revision

Homoserine Dehydrogenase in complex with 4-(4-hydroxy-3-isopropylphenylthio)-2-isopropylphenol

PDB ID 1tve

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