1c4p

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{{Seed}}
 
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[[Image:1c4p.png|left|200px]]
 
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==BETA DOMAIN OF STREPTOKINASE==
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The line below this paragraph, containing "STRUCTURE_1c4p", creates the "Structure Box" on the page.
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<StructureSection load='1c4p' size='340' side='right'caption='[[1c4p]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1c4p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_dysgalactiae_subsp._equisimilis Streptococcus dysgalactiae subsp. equisimilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C4P FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4p OCA], [https://pdbe.org/1c4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c4p RCSB], [https://www.ebi.ac.uk/pdbsum/1c4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c4p ProSAT]</span></td></tr>
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{{STRUCTURE_1c4p| PDB=1c4p | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q53284_STREQ Q53284_STREQ]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/1c4p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c4p ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Streptokinase, a 47 kDa secreted protein of hemolytic strains of streptococci, is a human plasminogen activator and contains three structural domains linked by flexible loops. We describe here the crystal structure of the isolated streptokinase middle (SKbeta) domain determined at 2.4 A resolution. Among the functionally important structural features is a putative binding site for a kringle domain of plasminogen located at the tip of a fully exposed hairpin loop. The distribution of genetically conserved residues of SKbeta is strongly correlated with their functions. The extensive interface of the SKbeta dimer suggests that such dimers may also exist in solution for free SKbeta.
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===BETA DOMAIN OF STREPTOKINASE===
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Crystal structure of streptokinase beta-domain.,Wang X, Tang J, Hunter B, Zhang XC FEBS Lett. 1999 Oct 1;459(1):85-9. PMID:10508922<ref>PMID:10508922</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1c4p" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10508922 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10508922}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1C4P is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Streptococcus_dysgalactiae_subsp._equisimilis Streptococcus dysgalactiae subsp. equisimilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4P OCA].
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==Reference==
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<ref group="xtra">PMID:10508922</ref><references group="xtra"/>
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[[Category: Streptococcus dysgalactiae subsp. equisimilis]]
[[Category: Streptococcus dysgalactiae subsp. equisimilis]]
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[[Category: Wang, X.]]
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[[Category: Wang X]]
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[[Category: Zhang, X C.]]
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[[Category: Zhang XC]]
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[[Category: Plasminogen activator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:08:56 2009''
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Current revision

BETA DOMAIN OF STREPTOKINASE

PDB ID 1c4p

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OCA

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