1osh

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{{Seed}}
 
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[[Image:1osh.png|left|200px]]
 
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==A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR==
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The line below this paragraph, containing "STRUCTURE_1osh", creates the "Structure Box" on the page.
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<StructureSection load='1osh' size='340' side='right'caption='[[1osh]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1osh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OSH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FEX:METHYL+3-{3-[(CYCLOHEXYLCARBONYL){[4-(DIMETHYLAMINO)BIPHENYL-4-YL]METHYL}AMINO]PHENYL}ACRYLATE'>FEX</scene></td></tr>
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{{STRUCTURE_1osh| PDB=1osh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1osh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osh OCA], [https://pdbe.org/1osh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1osh RCSB], [https://www.ebi.ac.uk/pdbsum/1osh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1osh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/1osh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1osh ConSurf].
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<div style="clear:both"></div>
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===A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR===
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==See Also==
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*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_12718892}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12718892 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_12718892}}
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==About this Structure==
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1OSH is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSH OCA].
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==Reference==
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<ref group="xtra">PMID:12718892</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Alvarez, J G.A.]]
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[[Category: Large Structures]]
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[[Category: Anisfeld, A M.]]
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[[Category: Alvarez JGA]]
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[[Category: Bowman, M E.]]
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[[Category: Anisfeld AM]]
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[[Category: Downes, M.]]
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[[Category: Bowman ME]]
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[[Category: Edwards, P A.]]
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[[Category: Downes M]]
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[[Category: Evans, R M.]]
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[[Category: Edwards PA]]
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[[Category: Ferrer, J L.]]
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[[Category: Evans RM]]
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[[Category: Hogenesch, J B.]]
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[[Category: Ferrer J-L]]
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[[Category: Hughes, R.]]
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[[Category: Hogenesch JB]]
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[[Category: Kast-Woelbern, H R.]]
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[[Category: Hughes R]]
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[[Category: Nicolaou, K C.]]
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[[Category: Kast-Woelbern HR]]
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[[Category: Noel, J P.]]
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[[Category: Nicolaou KC]]
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[[Category: Roecker, A J.]]
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[[Category: Noel JP]]
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[[Category: Rosenfeld, J M.]]
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[[Category: Roecker AJ]]
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[[Category: Verdecia, M A.]]
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[[Category: Rosenfeld JM]]
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[[Category: Ligand binding domain]]
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[[Category: Verdecia MA]]
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[[Category: Nuclear receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:10:40 2009''
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Current revision

A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR

PDB ID 1osh

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