1zpq

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(New page: 200px<br /><applet load="1zpq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zpq, resolution 2.8&Aring;" /> '''STRUCTURE OF BACTERIO...)
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[[Image:1zpq.gif|left|200px]]<br /><applet load="1zpq" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1zpq, resolution 2.8&Aring;" />
 
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'''STRUCTURE OF BACTERIOPHAGE LAMBDA CII protein'''<br />
 
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==Overview==
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==STRUCTURE OF BACTERIOPHAGE LAMBDA CII protein==
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The tetrameric cII protein from bacteriophage lambda activates, transcription from the phage promoters P(RE), P(I), and P(AQ) by binding, to two direct repeats that flank the promoter -35 element. Here, we, present the X-ray crystal structure of cII alone (2.8 A resolution) and in, complex with its DNA operator from P(RE) (1.7 A resolution). The, structures provide a basis for modeling of the activation complex with the, RNA polymerase holoenzyme, and point to the key role for the RNA, polymerase alpha subunit C-terminal domain (alphaCTD) in cII-dependent, activation, which forms a bridge of protein/protein interactions between, cII and the RNA polymerase sigma subunit. The model makes specific, predictions for protein/protein interactions between cII and alphaCTD, and, between alphaCTD and sigma, which are supported by previous genetic, studies.
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<StructureSection load='1zpq' size='340' side='right'caption='[[1zpq]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1zpq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_Lambda Escherichia virus Lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZPQ FirstGlance]. <br>
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1ZPQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ZPQ OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zpq OCA], [https://pdbe.org/1zpq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zpq RCSB], [https://www.ebi.ac.uk/pdbsum/1zpq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zpq ProSAT], [https://www.topsan.org/Proteins/MCSG/1zpq TOPSAN]</span></td></tr>
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==Reference==
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</table>
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Crystal structure of bacteriophage lambda cII and its DNA complex., Jain D, Kim Y, Maxwell KL, Beasley S, Zhang R, Gussin GN, Edwards AM, Darst SA, Mol Cell. 2005 Jul 22;19(2):259-69. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16039594 16039594]
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== Function ==
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[[Category: Enterobacteria phage lambda]]
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[https://www.uniprot.org/uniprot/RPC2_LAMBD RPC2_LAMBD] This protein and protein CIII form a complex that is involved in the initiation of lysogeny. The complex binds at either of the cy regulatory sites preceding the CI repressor protein and integrase coding regions and induces transcription of these genes.
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[[Category: Single protein]]
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== Evolutionary Conservation ==
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[[Category: Beasley, S.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Darst, S.A.]]
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Check<jmol>
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[[Category: Edwards, A.M.]]
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<jmolCheckbox>
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[[Category: Gussin, G.N.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zp/1zpq_consurf.spt"</scriptWhenChecked>
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[[Category: Jain, D.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Kim, Y.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: MCSG, Midwest.Center.for.Structural.Genomics.]]
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</jmolCheckbox>
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[[Category: Maxwell, K.L.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zpq ConSurf].
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[[Category: helix-turn-helix]]
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<div style="clear:both"></div>
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[[Category: mcsg]]
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__TOC__
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[[Category: midwest center for structural genomics]]
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</StructureSection>
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[[Category: protein structure initiative]]
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[[Category: Escherichia virus Lambda]]
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[[Category: psi]]
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[[Category: Large Structures]]
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[[Category: structural genomics]]
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[[Category: Beasley S]]
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[[Category: transcription activation]]
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[[Category: Darst SA]]
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[[Category: Edwards AM]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 07:35:27 2007''
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[[Category: Gussin GN]]
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[[Category: Jain D]]
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[[Category: Joachimiak A]]
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[[Category: Kim Y]]
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[[Category: Maxwell KL]]

Current revision

STRUCTURE OF BACTERIOPHAGE LAMBDA CII protein

PDB ID 1zpq

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