1kxr

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{{Seed}}
 
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[[Image:1kxr.png|left|200px]]
 
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==Crystal Structure of Calcium-Bound Protease Core of Calpain I==
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The line below this paragraph, containing "STRUCTURE_1kxr", creates the "Structure Box" on the page.
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<StructureSection load='1kxr' size='340' side='right'caption='[[1kxr]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kxr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KXR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_1kxr| PDB=1kxr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kxr OCA], [https://pdbe.org/1kxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kxr RCSB], [https://www.ebi.ac.uk/pdbsum/1kxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kxr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAN1_RAT CAN1_RAT] Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kx/1kxr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kxr ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ca(2+) signaling by calpains leads to controlled proteolysis during processes ranging from cytoskeleton remodeling in mammals to sex determination in nematodes. Deregulated Ca(2+) levels result in aberrant proteolysis by calpains, which contributes to tissue damage in heart and brain ischemias as well as neurodegeneration in Alzheimer's disease. Here we show that activation of the protease core of mu calpain requires cooperative binding of two Ca(2+) atoms at two non-EF-hand sites revealed in the 2.1 A crystal structure. Conservation of the Ca(2+) binding residues defines an ancestral general mechanism of activation for most calpain isoforms, including some that lack EF-hand domains. The protease region is not affected by the endogenous inhibitor, calpastatin, and may contribute to calpain-mediated pathologies when the core is released by autoproteolysis.
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===Crystal Structure of Calcium-Bound Protease Core of Calpain I===
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A Ca(2+) switch aligns the active site of calpain.,Moldoveanu T, Hosfield CM, Lim D, Elce JS, Jia Z, Davies PL Cell. 2002 Mar 8;108(5):649-60. PMID:11893336<ref>PMID:11893336</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1kxr" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_11893336}}, adds the Publication Abstract to the page
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*[[Calpain 3D structures|Calpain 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11893336 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11893336}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1KXR is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXR OCA].
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==Reference==
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<ref group="xtra">PMID:11893336</ref><references group="xtra"/>
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[[Category: Hydrolase]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Davies, P L.]]
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[[Category: Davies PL]]
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[[Category: Elce, J S.]]
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[[Category: Elce JS]]
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[[Category: Hosfield, C M.]]
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[[Category: Hosfield CM]]
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[[Category: Jia, Z.]]
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[[Category: Jia Z]]
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[[Category: Lim, D.]]
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[[Category: Lim D]]
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[[Category: Moldoveanu, T.]]
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[[Category: Moldoveanu T]]
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[[Category: Calcium-dependent cysteine protease]]
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[[Category: Papain-related]]
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[[Category: Two novel cooperative calcium site]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:28:48 2009''
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Current revision

Crystal Structure of Calcium-Bound Protease Core of Calpain I

PDB ID 1kxr

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