2hlh

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{{Seed}}
 
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[[Image:2hlh.png|left|200px]]
 
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==Crystal structure of fucosyltransferase NodZ from Bradyrhizobium==
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The line below this paragraph, containing "STRUCTURE_2hlh", creates the "Structure Box" on the page.
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<StructureSection load='2hlh' size='340' side='right'caption='[[2hlh]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2hlh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bradyrhizobium_sp._WM9 Bradyrhizobium sp. WM9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HLH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HLH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_2hlh| PDB=2hlh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hlh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hlh OCA], [https://pdbe.org/2hlh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hlh RCSB], [https://www.ebi.ac.uk/pdbsum/2hlh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hlh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9AQ17_BRASW Q9AQ17_BRASW]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/2hlh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hlh ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The fucosyltransferase NodZ is involved in the biosynthesis of the nodulation factor in nitrogen-fixing symbiotic bacteria. It catalyzes alpha1,6 transfer of l-fucose from GDP-fucose to the reducing residue of the synthesized Nod oligosaccharide. We present the structure of the NodZ protein from Bradyrhizobium expressed in Escherichia coli and crystallized in the presence of phosphate ions in two crystal forms. The enzyme is arranged into two domains of nearly equal size. Although NodZ falls in one broad class (GT-B) with other two-domain glycosyltransferases, the topology of its domains deviates from the canonical Rossmann fold, with particularly high distortions in the N-terminal domain. Mutational data combined with structural and sequence alignments indicate residues of potential importance in GDP-fucose binding or in the catalytic mechanism. They are all clustered in three conserved sequence motifs located in the C-terminal domain.
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===Crystal structure of fucosyltransferase NodZ from Bradyrhizobium===
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High-resolution structure of NodZ fucosyltransferase involved in the biosynthesis of the nodulation factor.,Brzezinski K, Stepkowski T, Panjikar S, Bujacz G, Jaskolski M Acta Biochim Pol. 2007;54(3):537-49. Epub 2007 Aug 30. PMID:17762900<ref>PMID:17762900</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2hlh" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17762900}}, adds the Publication Abstract to the page
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*[[NodS|NodS]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17762900 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17762900}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Bradyrhizobium sp. WM9]]
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2HLH is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bradyrhizobium_sp. Bradyrhizobium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HLH OCA].
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[[Category: Large Structures]]
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[[Category: Brzezinski K]]
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==Reference==
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[[Category: Bujacz G]]
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<ref group="xtra">PMID:17762900</ref><references group="xtra"/>
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[[Category: Jaskolski M]]
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[[Category: Bradyrhizobium sp.]]
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[[Category: Panjikar S]]
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[[Category: Brzezinski, K.]]
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[[Category: Stepkowski T]]
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[[Category: Bujacz, G.]]
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[[Category: Jaskolski, M.]]
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[[Category: Panjikar, S.]]
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[[Category: Stepkowski, T.]]
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[[Category: Fucosyltransferase]]
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[[Category: Glycosyltransferase]]
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[[Category: Nodulation]]
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[[Category: Nodz]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:33:06 2009''
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Current revision

Crystal structure of fucosyltransferase NodZ from Bradyrhizobium

PDB ID 2hlh

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