1zj6

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{{Seed}}
 
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[[Image:1zj6.png|left|200px]]
 
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==Crystal structure of human ARL5==
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The line below this paragraph, containing "STRUCTURE_1zj6", creates the "Structure Box" on the page.
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<StructureSection load='1zj6' size='340' side='right'caption='[[1zj6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zj6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZJ6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G3D:GUANOSINE-3-MONOPHOSPHATE-5-DIPHOSPHATE'>G3D</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1zj6| PDB=1zj6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zj6 OCA], [https://pdbe.org/1zj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zj6 RCSB], [https://www.ebi.ac.uk/pdbsum/1zj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zj6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARL5A_HUMAN ARL5A_HUMAN] Lacks ADP-ribosylation enhancing activity (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zj/1zj6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zj6 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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ARL5 is a member of ARLs, which is widespread in high eukaryotes and homologous between species. But no structure or biological function of this member is reported. We expressed, purified, and resolved the structure of human ARL5 with bound GDP3'P at 2.0 A resolution. A comparison with the known structures of ARFs shows that besides the typical features of ARFs, human ARL5 has specific features of its own. Bacterially expressed human ARL5 contains bound GDP3'P which is seldom seen in other structures. The hydrophobic tail of the introduced detergent Triton X-305 binds at the possible myristoylation site of Gly2, simulating the myristoylated state of N-terminal amphipathic helix in vivo. The structural features of the nucleotide binding motifs and the switch regions prove that ARL5 will undergo the typical GDP/GTP structural cycle as other members of ARLs, which is the basis of their biological functions.
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===Crystal structure of human ARL5===
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2.0 A crystal structure of human ARL5-GDP3'P, a novel member of the small GTP-binding proteins.,Wang ZX, Shi L, Liu JF, An XM, Chang WR, Liang DC Biochem Biophys Res Commun. 2005 Jul 8;332(3):640-5. PMID:15896705<ref>PMID:15896705</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15896705}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1zj6" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15896705 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15896705}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1ZJ6 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZJ6 OCA].
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==Reference==
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<ref group="xtra">PMID:15896705</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: An, X M.]]
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[[Category: Large Structures]]
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[[Category: Chang, W R.]]
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[[Category: An XM]]
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[[Category: Liang, D C.]]
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[[Category: Chang WR]]
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[[Category: Liu, J F.]]
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[[Category: Liang DC]]
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[[Category: Shi, L.]]
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[[Category: Liu JF]]
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[[Category: Wang, Z X.]]
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[[Category: Shi L]]
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[[Category: Arl]]
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[[Category: Wang ZX]]
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[[Category: Gtp-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:59:08 2009''
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Current revision

Crystal structure of human ARL5

PDB ID 1zj6

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