1c3y

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{{Seed}}
 
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[[Image:1c3y.png|left|200px]]
 
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==THP12-CARRIER PROTEIN FROM YELLOW MEAL WORM==
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The line below this paragraph, containing "STRUCTURE_1c3y", creates the "Structure Box" on the page.
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<StructureSection load='1c3y' size='340' side='right'caption='[[1c3y]]' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1c3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tenebrio_molitor Tenebrio molitor]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C3Y FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 23 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c3y OCA], [https://pdbe.org/1c3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c3y RCSB], [https://www.ebi.ac.uk/pdbsum/1c3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c3y ProSAT]</span></td></tr>
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{{STRUCTURE_1c3y| PDB=1c3y | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q27011_TENMO Q27011_TENMO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c3/1c3y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c3y ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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BACKGROUND: THP12 is an abundant and extraordinarily hydrophilic hemolymph protein from the mealworm Tenebrio molitor and belongs to a group of small insect proteins with four highly conserved cysteine residues. Despite their sequence homology to odorant-binding proteins and pheromone-binding proteins, the function of these proteins is unclear. RESULTS: The first three-dimensional structure of THP12 has been determined by multidimensional NMR spectroscopy. The protein has a nonbundle helical structure consisting of six alpha helices. The arrangement of the alpha helices has a 'baseball glove' shape. In addition to the hydrophobic core, electrostatic interactions make contributions to the overall stability of the protein. NMR binding studies demonstrated the binding of small hydrophobic ligands to the single hydrophobic groove in THP12. Comparing the structure of THP12 with the predicted secondary structure of homologs reveals a common fold for this new class of insect proteins. A search with the program DALI revealed extensive similarity between the three-dimensional structure of THP12 and the N-terminal domain (residues 1-95) of recoverin, a member of the family of calcium-binding EF-hand proteins. CONCLUSIONS: Although the biological function of this new class of proteins is as yet undetermined, a general role as alpha-helical carrier proteins for small hydrophobic ligands, such as fatty acids or pheromones, is proposed on the basis of NMR-shift perturbation spectroscopy.
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===THP12-CARRIER PROTEIN FROM YELLOW MEAL WORM===
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A new class of hexahelical insect proteins revealed as putative carriers of small hydrophobic ligands.,Rothemund S, Liou YC, Davies PL, Krause E, Sonnichsen FD Structure. 1999 Nov 15;7(11):1325-32. PMID:10574794<ref>PMID:10574794</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1c3y" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10574794 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10574794}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1C3Y is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Tenebrio_molitor Tenebrio molitor]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C3Y OCA].
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==Reference==
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<ref group="xtra">PMID:10574794</ref><references group="xtra"/>
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[[Category: Tenebrio molitor]]
[[Category: Tenebrio molitor]]
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[[Category: Soennichsen, F D.]]
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[[Category: Soennichsen FD]]
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[[Category: All-alpha]]
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[[Category: Ef-hand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:33:12 2009''
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Current revision

THP12-CARRIER PROTEIN FROM YELLOW MEAL WORM

PDB ID 1c3y

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