1joy

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{{Seed}}
 
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[[Image:1joy.png|left|200px]]
 
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==SOLUTION STRUCTURE OF THE HOMODIMERIC DOMAIN OF ENVZ FROM ESCHERICHIA COLI BY MULTI-DIMENSIONAL NMR.==
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The line below this paragraph, containing "STRUCTURE_1joy", creates the "Structure Box" on the page.
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<StructureSection load='1joy' size='340' side='right'caption='[[1joy]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1joy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JOY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1joy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1joy OCA], [https://pdbe.org/1joy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1joy RCSB], [https://www.ebi.ac.uk/pdbsum/1joy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1joy ProSAT]</span></td></tr>
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{{STRUCTURE_1joy| PDB=1joy | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ENVZ_ECOLI ENVZ_ECOLI] Member of the two-component regulatory system EnvZ/OmpR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jo/1joy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1joy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Escherichia coli osmosensor EnvZ is a protein histidine kinase that plays a central role in osmoregulation, a cellular adaptation process involving the His-Asp phosphorelay signal transduction system. Dimerization of the transmembrane protein is essential for its autophosphorylation and phosphorelay signal transduction functions. Here we present the NMR-derived structure of the homodimeric core domain (residues 223-289) of EnvZ that includes His 243, the site of autophosphorylation and phosphate transfer reactions. The structure comprises a four-helix bundle formed by two identical helix-turn-helix subunits, revealing the molecular assembly of two active sites within the dimeric kinase.
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===SOLUTION STRUCTURE OF THE HOMODIMERIC DOMAIN OF ENVZ FROM ESCHERICHIA COLI BY MULTI-DIMENSIONAL NMR.===
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Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ.,Tomomori C, Tanaka T, Dutta R, Park H, Saha SK, Zhu Y, Ishima R, Liu D, Tong KI, Kurokawa H, Qian H, Inouye M, Ikura M Nat Struct Biol. 1999 Aug;6(8):729-34. PMID:10426948<ref>PMID:10426948</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_10426948}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1joy" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10426948 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10426948}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1JOY is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOY OCA].
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==Reference==
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<ref group="xtra">PMID:10426948</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Dutta, R.]]
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[[Category: Large Structures]]
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[[Category: Ikura, M.]]
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[[Category: Dutta R]]
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[[Category: Inouye, M.]]
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[[Category: Ikura M]]
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[[Category: Ishima, R.]]
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[[Category: Inouye M]]
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[[Category: Kurokawa, H.]]
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[[Category: Ishima R]]
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[[Category: Liu, D.]]
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[[Category: Kurokawa H]]
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[[Category: Park, H.]]
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[[Category: Liu D]]
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[[Category: Qian, H.]]
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[[Category: Park H]]
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[[Category: Saha, S K.]]
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[[Category: Qian H]]
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[[Category: Tanaka, T.]]
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[[Category: Saha SK]]
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[[Category: Tomomori, C.]]
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[[Category: Tanaka T]]
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[[Category: Tong, K I.]]
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[[Category: Tomomori C]]
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[[Category: Zhu, Y.]]
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[[Category: Tong KI]]
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[[Category: Histidine kinase]]
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[[Category: Zhu Y]]
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[[Category: Inner membrane]]
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[[Category: Osmolarity sensor protein]]
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[[Category: Phosphorylation]]
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[[Category: Sensory transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:39:53 2009''
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Current revision

SOLUTION STRUCTURE OF THE HOMODIMERIC DOMAIN OF ENVZ FROM ESCHERICHIA COLI BY MULTI-DIMENSIONAL NMR.

PDB ID 1joy

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