2e2y

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{{Seed}}
 
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[[Image:2e2y.png|left|200px]]
 
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==Crystal Structure of F43W/H64D/V68I Myoglobin==
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The line below this paragraph, containing "STRUCTURE_2e2y", creates the "Structure Box" on the page.
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<StructureSection load='2e2y' size='340' side='right'caption='[[2e2y]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2e2y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E2Y FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2e2y| PDB=2e2y | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2y OCA], [https://pdbe.org/2e2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e2y RCSB], [https://www.ebi.ac.uk/pdbsum/2e2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e2y ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYG_PHYMC MYG_PHYMC] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/2e2y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e2y ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A series of myoglobin mutants, in which distal sites are modified by site-directed mutagenesis, are able to catalyze peroxidase, catalase, and P450 reactions even though their proximal histidine ligands are intact. More importantly, reactions of P450, catalase, and peroxidase substrates and compound I of myoglobin mutants can be observed spectroscopically. Thus, detailed oxidation mechanisms were examined. On the basis of these results, we suggest that the different reactivities of P450, catalase, and peroxidase are mainly caused by their active site structures, but not the axial ligand. We have also prepared compound 0 under physiological conditions by employing a mutant of cytochrome c 552. Compound 0 is not able to oxidize ascorbic acid.
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===Crystal Structure of F43W/H64D/V68I Myoglobin===
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Reactivities of oxo and peroxo intermediates studied by hemoprotein mutants.,Watanabe Y, Nakajima H, Ueno T Acc Chem Res. 2007 Jul;40(7):554-62. Epub 2007 Jun 14. PMID:17567089<ref>PMID:17567089</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2e2y" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17567089}}, adds the Publication Abstract to the page
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*[[Myoglobin 3D structures|Myoglobin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17567089 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17567089}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2E2Y is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2Y OCA].
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==Reference==
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<ref group="xtra">PMID:17567089</ref><references group="xtra"/>
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[[Category: Physeter catodon]]
[[Category: Physeter catodon]]
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[[Category: Hikage, T.]]
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[[Category: Hikage T]]
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[[Category: Ohki, T.]]
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[[Category: Ohki T]]
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[[Category: Suzuki, A.]]
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[[Category: Suzuki A]]
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[[Category: Ueno, T.]]
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[[Category: Ueno T]]
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[[Category: Watanabe, Y.]]
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[[Category: Watanabe Y]]
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[[Category: Yamane, T.]]
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[[Category: Yamane T]]
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[[Category: Oxygen storage/transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:45:18 2009''
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Current revision

Crystal Structure of F43W/H64D/V68I Myoglobin

PDB ID 2e2y

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