1pnr

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{{Seed}}
 
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[[Image:1pnr.png|left|200px]]
 
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==PURINE REPRESSOR-HYPOXANTHINE-PURF-OPERATOR COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1pnr", creates the "Structure Box" on the page.
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<StructureSection load='1pnr' size='340' side='right'caption='[[1pnr]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pnr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PNR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HPA:HYPOXANTHINE'>HPA</scene></td></tr>
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{{STRUCTURE_1pnr| PDB=1pnr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pnr OCA], [https://pdbe.org/1pnr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pnr RCSB], [https://www.ebi.ac.uk/pdbsum/1pnr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pnr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PURR_ECOLI PURR_ECOLI] Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. In addition, it participates in the regulation or coregulation of genes involved in de novo pyrimidine nucleotide biosynthesis, salvage and uptake (pyrC, pyrD, carAB and codBA), and of several genes encoding enzymes necessary for nucleotide and polyamine biosynthesis (prsA, glyA, gcvTHP, speA, glnB). Binds to a 16-bp palindromic sequence located within the promoter region of pur regulon genes. The consensus binding sequence is 5'-ACGCAAACGTTTTCNT-3'. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.<ref>PMID:2404765</ref> <ref>PMID:2211500</ref> <ref>PMID:1400170</ref> <ref>PMID:14741201</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/1pnr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pnr ConSurf].
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<div style="clear:both"></div>
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===PURINE REPRESSOR-HYPOXANTHINE-PURF-OPERATOR COMPLEX===
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==See Also==
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*[[Purine repressor|Purine repressor]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_7973627}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 7973627 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_7973627}}
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==About this Structure==
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1PNR is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PNR OCA].
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==Reference==
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<ref group="xtra">PMID:7973627</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Brennan, R G.]]
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[[Category: Large Structures]]
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[[Category: Choi, K Y.]]
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[[Category: Brennan RG]]
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[[Category: Schumacher, M A.]]
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[[Category: Choi KY]]
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[[Category: Zalkin, H.]]
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[[Category: Schumacher MA]]
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[[Category: Protein-dna complex]]
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[[Category: Zalkin H]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:55:35 2009''
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Current revision

PURINE REPRESSOR-HYPOXANTHINE-PURF-OPERATOR COMPLEX

PDB ID 1pnr

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