1k0h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:12, 29 May 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1k0h.png|left|200px]]
 
-
<!--
+
==Solution structure of bacteriophage lambda gpFII==
-
The line below this paragraph, containing "STRUCTURE_1k0h", creates the "Structure Box" on the page.
+
<StructureSection load='1k0h' size='340' side='right'caption='[[1k0h]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1k0h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_Lambda Escherichia virus Lambda]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K0H FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k0h OCA], [https://pdbe.org/1k0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k0h RCSB], [https://www.ebi.ac.uk/pdbsum/1k0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k0h ProSAT]</span></td></tr>
-
{{STRUCTURE_1k0h| PDB=1k0h | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/FII_LAMBD FII_LAMBD] Plays a role in virion assembly by joining the head and the tail at the last step of morphogenesis. Six FII proteins bind the DNA-filled capsid after W binding, in turn binding the pre-assembled tail by interacting with U protein.<ref>PMID:4413519</ref> <ref>PMID:4616093</ref> <ref>PMID:5022189</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k0/1k0h_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k0h ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The bacteriophage lambda FII protein (gpFII) is a 117 residue structural protein found in the phage particle that is required for the joining of phage heads and tails at the last step of morphogenesis. We have performed biophysical experiments to show that gpFII is stable, monomeric, and reversibly folded. We have also determined the atomic resolution structure of gpFII using NMR spectroscopy. gpFII is shown to possess a novel fold consisting of seven beta-strands and a short alpha-helix. It also displays two large unstructured regions at the N terminus (residues 1-24) and in a large loop near the middle of the protein (residues 46-62). We speculate that these unstructured regions become structured when gpFII assembles into the phage particle, and that these conformational changes play an important role in regulating the assembly pathway. Alignment of the gpFII sequence with those of homologues from other lambdoid phages has allowed us to putatively identify distinct surfaces on the gpFII structure that mediate binding to the phage head and tail.
-
===Solution structure of bacteriophage lambda gpFII===
+
The solution structure of the bacteriophage lambda head-tail joining protein, gpFII.,Maxwell KL, Yee AA, Arrowsmith CH, Gold M, Davidson AR J Mol Biol. 2002 May 17;318(5):1395-404. PMID:12083526<ref>PMID:12083526</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_12083526}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1k0h" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 12083526 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_12083526}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Escherichia virus Lambda]]
-
1K0H is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0H OCA].
+
[[Category: Large Structures]]
-
 
+
[[Category: Arrowsmith CH]]
-
==Reference==
+
[[Category: Davidson AR]]
-
<ref group="xtra">PMID:12083526</ref><references group="xtra"/>
+
[[Category: Gold M]]
-
[[Category: Enterobacteria phage lambda]]
+
[[Category: Maxwell KL]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Yee AA]]
-
[[Category: Davidson, A R.]]
+
-
[[Category: Gold, M.]]
+
-
[[Category: Maxwell, K L.]]
+
-
[[Category: Yee, A A.]]
+
-
[[Category: Twisted beta-sandwich]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 00:02:14 2009''
+

Current revision

Solution structure of bacteriophage lambda gpFII

PDB ID 1k0h

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k0h"
Personal tools