2cme

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{{Seed}}
 
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[[Image:2cme.png|left|200px]]
 
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==The crystal structure of SARS coronavirus ORF-9b protein==
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The line below this paragraph, containing "STRUCTURE_2cme", creates the "Structure Box" on the page.
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<StructureSection load='2cme' size='340' side='right'caption='[[2cme]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2cme]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome-related_coronavirus Severe acute respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CME FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D10:DECANE'>D10</scene></td></tr>
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{{STRUCTURE_2cme| PDB=2cme | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cme OCA], [https://pdbe.org/2cme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cme RCSB], [https://www.ebi.ac.uk/pdbsum/2cme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cme ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ORF9B_SARS ORF9B_SARS] Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, causes mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin-like protein 1/DNM1L.<ref>PMID:25135833</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cme_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cme ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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To achieve the greatest output from their limited genomes, viruses frequently make use of alternative open reading frames, in which translation is initiated from a start codon within an existing gene and, being out of frame, gives rise to a distinct protein product. These alternative protein products are, as yet, poorly characterized structurally. Here we report the crystal structure of ORF-9b, an alternative open reading frame within the nucleocapsid (N) gene from the SARS coronavirus. The protein has a novel fold, a dimeric tent-like beta structure with an amphipathic surface, and a central hydrophobic cavity that binds lipid molecules. This cavity is likely to be involved in membrane attachment and, in mammalian cells, ORF-9b associates with intracellular vesicles, consistent with a role in the assembly of the virion. Analysis of ORF-9b and other overlapping genes suggests that they provide snapshots of the early evolution of novel protein folds.
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===THE CRYSTAL STRUCTURE OF SARS CORONAVIRUS ORF-9B PROTEIN===
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The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus.,Meier C, Aricescu AR, Assenberg R, Aplin RT, Gilbert RJ, Grimes JM, Stuart DI Structure. 2006 Jul;14(7):1157-65. PMID:16843897<ref>PMID:16843897</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2cme" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16843897 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16843897}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2CME is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CME OCA].
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[[Category: Severe acute respiratory syndrome-related coronavirus]]
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[[Category: Aplin RT]]
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==Reference==
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[[Category: Aricescu AR]]
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<ref group="xtra">PMID:16843897</ref><references group="xtra"/>
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[[Category: Assenberg R]]
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[[Category: Human sars coronavirus]]
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[[Category: Gilbert RJC]]
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[[Category: Aplin, R T.]]
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[[Category: Grimes JM]]
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[[Category: Aricescu, A R.]]
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[[Category: Meier C]]
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[[Category: Assenberg, R.]]
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[[Category: Stuart DI]]
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[[Category: Gilbert, R J.C.]]
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[[Category: Grimes, J M.]]
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[[Category: Meier, C.]]
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[[Category: Stuart, D I.]]
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[[Category: Alternative open reading frame]]
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[[Category: Hypothetical protein]]
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[[Category: Lipid-binding]]
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[[Category: Virus assembly]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 00:06:54 2009''
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Current revision

The crystal structure of SARS coronavirus ORF-9b protein

PDB ID 2cme

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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