2von

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[[Image:2von.png|left|200px]]
 
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==Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAAUUU==
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The line below this paragraph, containing "STRUCTURE_2von", creates the "Structure Box" on the page.
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<StructureSection load='2von' size='340' side='right'caption='[[2von]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2von]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VON FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2von FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2von OCA], [https://pdbe.org/2von PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2von RCSB], [https://www.ebi.ac.uk/pdbsum/2von PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2von ProSAT]</span></td></tr>
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{{STRUCTURE_2von| PDB=2von | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LA_HUMAN LA_HUMAN] Binds to the 3' poly(U) terminii of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.<ref>PMID:3192525</ref> <ref>PMID:2470590</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2von_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2von ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The eukaryotic La protein recognizes the 3' poly(U) sequences of nascent RNA polymerase III transcripts to assist folding and maturation. The 3' ends of such RNAs are bound by the N-terminal domain of La (LaNTD). We have solved the crystal structures of four LaNTD:RNA complexes, each containing a different single-stranded RNA oligomer, and compared them to the structure of a previously published LaNTD:RNA complex containing partially duplex RNA. The presence of purely single-stranded RNA in the binding pocket at the interface between the La motif and RRM domains allows significantly closer contact with the 3' end of the RNA. Comparison of the different LaNTD:RNA complexes identifies a conserved set of interactions with the last two nucleotides at the 3' end of the RNA ligand that are key to binding. Strikingly, we also observe two alternative conformations of bound ssRNA, indicative of an unexpected degree of plasticity in the modes of RNA binding.
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===CRYSTAL STRUCTURE OF N-TERMINAL DOMAINS OF HUMAN LA PROTEIN COMPLEXED WITH RNA OLIGOMER AUAAUUU===
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Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein.,Kotik-Kogan O, Valentine ER, Sanfelice D, Conte MR, Curry S Structure. 2008 Jun;16(6):852-62. PMID:18547518<ref>PMID:18547518</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18547518}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2von" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18547518 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18547518}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2VON is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VON OCA].
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==Reference==
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<ref group="xtra">PMID:18547518</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Conte, M R.]]
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[[Category: Large Structures]]
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[[Category: Curry, S.]]
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[[Category: Conte MR]]
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[[Category: Kotik-Kogan, O.]]
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[[Category: Curry S]]
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[[Category: Sanfelice, D.]]
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[[Category: Kotik-Kogan O]]
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[[Category: Valentine, E R.]]
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[[Category: Sanfelice D]]
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[[Category: La motif]]
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[[Category: Valentine ER]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Rna binding protein]]
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[[Category: Rna maturation]]
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[[Category: Rna recognition motif]]
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[[Category: Rna-binding]]
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[[Category: Rna-binding protein]]
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[[Category: Systemic lupus erythematosus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 00:24:53 2009''
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Current revision

Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAAUUU

PDB ID 2von

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