1h29

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (04:34, 17 October 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1h29.png|left|200px]]
 
-
<!--
+
==Sulfate respiration in Desulfovibrio vulgaris Hildenborough: Structure of the 16-heme Cytochrome c HmcA at 2.5 A resolution and a view of its role in transmembrane electron transfer==
-
The line below this paragraph, containing "STRUCTURE_1h29", creates the "Structure Box" on the page.
+
<StructureSection load='1h29' size='340' side='right'caption='[[1h29]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1h29]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfovibrio_vulgaris_str._Hildenborough Desulfovibrio vulgaris str. Hildenborough]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H29 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
-
{{STRUCTURE_1h29| PDB=1h29 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h29 OCA], [https://pdbe.org/1h29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h29 RCSB], [https://www.ebi.ac.uk/pdbsum/1h29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h29 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HMWC_NITV2 HMWC_NITV2] HMWC (high-molecular-weight cytochrome c), ORF2, ORF3, ORF4, ORF5 and ORF6 in the HMC operon form a transmembrane protein complex that allows electron flow from the periplasmic hydrogenase to the cytoplasmic enzymes that catalyze reduction of sulfates.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h2/1h29_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h29 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The crystal structure of the high molecular mass cytochrome c HmcA from Desulfovibrio vulgaris Hildenborough is described. HmcA contains the unprecedented number of sixteen hemes c attached to a single polypeptide chain, is associated with a membrane-bound redox complex, and is involved in electron transfer from the periplasmic oxidation of hydrogen to the cytoplasmic reduction of sulfate. The structure of HmcA is organized into four tetraheme cytochrome c(3)-like domains, of which the first is incomplete and contains only three hemes, and the final two show great similarity to the nine-heme cytochrome c from Desulfovibrio desulfuricans. An isoleucine residue fills the vacant coordination space above the iron atom in the five-coordinated high-spin Heme 15. The characteristics of each of the tetraheme domains of HmcA, as well as its surface charge distribution, indicate this cytochrome has several similarities with the nine-heme cytochrome c and the Type II cytochrome c(3) molecules, in agreement with their similar genetic organization and mode of reactivity and further support an analogous physiological function for the three cytochromes. Based on the present structure, the possible electron transfer sites between HmcA and its redox partners (namely Type I cytochrome c(3) and other proteins of the Hmc complex), as well as its physiological role, are discussed.
-
===SULFATE RESPIRATION IN DESULFOVIBRIO VULGARIS HILDENBOROUGH: STRUCTURE OF THE 16-HEME CYTOCHROME C HMCA AT 2.5 A RESOLUTION AND A VIEW OF ITS ROLE IN TRANSMEMBRANE ELECTRON TRANSFER===
+
Sulfate respiration in Desulfovibrio vulgaris Hildenborough. Structure of the 16-heme cytochrome c HmcA AT 2.5-A resolution and a view of its role in transmembrane electron transfer.,Matias PM, Coelho AV, Valente FM, Placido D, LeGall J, Xavier AV, Pereira IA, Carrondo MA J Biol Chem. 2002 Dec 6;277(49):47907-16. Epub 2002 Sep 27. PMID:12356749<ref>PMID:12356749</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1h29" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
1H29 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Desulfovibrio_vulgaris Desulfovibrio vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H29 OCA].
+
*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
-
[[Category: Desulfovibrio vulgaris]]
+
== References ==
-
[[Category: Carrondo, M A.]]
+
<references/>
-
[[Category: Coelho, A V.]]
+
__TOC__
-
[[Category: Legall, J.]]
+
</StructureSection>
-
[[Category: Matias, P M.]]
+
[[Category: Desulfovibrio vulgaris str. Hildenborough]]
-
[[Category: Pereira, I A.C.]]
+
[[Category: Large Structures]]
-
[[Category: Placido, D.]]
+
[[Category: Carrondo MA]]
-
[[Category: Valente, F M.A.]]
+
[[Category: Coelho AV]]
-
[[Category: Xavier, A V.]]
+
[[Category: Legall J]]
-
[[Category: C3-like domain]]
+
[[Category: Matias PM]]
-
[[Category: Electron transport]]
+
[[Category: Pereira IAC]]
-
[[Category: Energy conservation]]
+
[[Category: Placido D]]
-
[[Category: High molecular mass cytochrome]]
+
[[Category: Valente FMA]]
-
[[Category: Hydrogen cycle]]
+
[[Category: Xavier AV]]
-
[[Category: Proton gradient]]
+
-
[[Category: Sulfate respiration]]
+
-
[[Category: Tetra-heme]]
+
-
[[Category: Transmembrane redox complex]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 00:26:01 2009''
+

Current revision

Sulfate respiration in Desulfovibrio vulgaris Hildenborough: Structure of the 16-heme Cytochrome c HmcA at 2.5 A resolution and a view of its role in transmembrane electron transfer

PDB ID 1h29

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1h29"
Personal tools