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2jx8

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{{Seed}}
 
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[[Image:2jx8.png|left|200px]]
 
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<!--
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==Solution structure of hPCIF1 WW domain==
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The line below this paragraph, containing "STRUCTURE_2jx8", creates the "Structure Box" on the page.
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<StructureSection load='2jx8' size='340' side='right'caption='[[2jx8]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jx8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JX8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx8 OCA], [https://pdbe.org/2jx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jx8 RCSB], [https://www.ebi.ac.uk/pdbsum/2jx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx8 ProSAT]</span></td></tr>
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{{STRUCTURE_2jx8| PDB=2jx8 | SCENE= }}
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</table>
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== Function ==
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===Solution structure of hPCIF1 WW domain===
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[https://www.uniprot.org/uniprot/CAPAM_HUMAN CAPAM_HUMAN] Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659, PubMed:33428944). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178).<ref>PMID:30467178</ref> <ref>PMID:30487554</ref> <ref>PMID:31279658</ref> <ref>PMID:31279659</ref> <ref>PMID:33428944</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2JX8 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX8 OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jx8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jx8 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Aizawa, T.]]
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[[Category: Large Structures]]
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[[Category: Demura, M.]]
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[[Category: Aizawa T]]
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[[Category: Hirose, Y.]]
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[[Category: Demura M]]
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[[Category: Iwamoto, Y.]]
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[[Category: Hirose Y]]
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[[Category: Kawano, K.]]
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[[Category: Iwamoto Y]]
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[[Category: Kouno, T.]]
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[[Category: Kawano K]]
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[[Category: Mizuguchi, M.]]
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[[Category: Kouno T]]
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[[Category: Ohkuma, Y.]]
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[[Category: Mizuguchi M]]
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[[Category: Alpha-helix]]
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[[Category: Ohkuma Y]]
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[[Category: Nucleus]]
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[[Category: Phosphorylation]]
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[[Category: Protein fragment]]
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[[Category: Transcription]]
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[[Category: Triple-standed beta-sheet]]
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[[Category: Ww domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 00:38:11 2009''
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Current revision

Solution structure of hPCIF1 WW domain

PDB ID 2jx8

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OCA

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