2hix

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{{Seed}}
 
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[[Image:2hix.png|left|200px]]
 
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==ATP dependent DNA ligase from S. solfataricus bound to ATP==
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The line below this paragraph, containing "STRUCTURE_2hix", creates the "Structure Box" on the page.
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<StructureSection load='2hix' size='340' side='right'caption='[[2hix]], [[Resolution|resolution]] 2.87&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2hix]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HIX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.87&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
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{{STRUCTURE_2hix| PDB=2hix | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hix OCA], [https://pdbe.org/2hix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hix RCSB], [https://www.ebi.ac.uk/pdbsum/2hix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hix ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DNLI_SACS2 DNLI_SACS2] DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Interaction with PCNA enhances ligase activity. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.<ref>PMID:12535540</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hi/2hix_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hix ConSurf].
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<div style="clear:both"></div>
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===ATP dependent DNA ligase from S. solfataricus bound to ATP===
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==See Also==
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*[[DNA ligase|DNA ligase]]
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*[[DNA ligase 3D structures|DNA ligase 3D structures]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_17052461}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 17052461 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_17052461}}
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[[Category: Large Structures]]
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[[Category: Saccharolobus solfataricus]]
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==About this Structure==
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[[Category: Ellenberger T]]
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2HIX is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HIX OCA].
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[[Category: Pascal JM]]
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==Reference==
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<ref group="xtra">PMID:17052461</ref><references group="xtra"/>
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[[Category: Sulfolobus solfataricus]]
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[[Category: Ellenberger, T.]]
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[[Category: Pascal, J M.]]
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[[Category: Atp-dependent dna ligase]]
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[[Category: Dna replication]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 00:42:33 2009''
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Current revision

ATP dependent DNA ligase from S. solfataricus bound to ATP

PDB ID 2hix

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