2vr2

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{{Seed}}
 
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[[Image:2vr2.png|left|200px]]
 
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==Human Dihydropyrimidinase==
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The line below this paragraph, containing "STRUCTURE_2vr2", creates the "Structure Box" on the page.
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<StructureSection load='2vr2' size='340' side='right'caption='[[2vr2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vr2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VR2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2vr2| PDB=2vr2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr2 OCA], [https://pdbe.org/2vr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vr2 RCSB], [https://www.ebi.ac.uk/pdbsum/2vr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vr2 ProSAT]</span></td></tr>
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</table>
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===HUMAN DIHYDROPYRIMIDINASE===
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== Disease ==
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[https://www.uniprot.org/uniprot/DPYS_HUMAN DPYS_HUMAN] Dihydropyrimidinuria. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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==About this Structure==
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[https://www.uniprot.org/uniprot/DPYS_HUMAN DPYS_HUMAN] Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.
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2VR2 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR2 OCA].
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== Evolutionary Conservation ==
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[[Category: Dihydropyrimidinase]]
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/2vr2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vr2 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Andersson, J.]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Andersson J]]
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[[Category: Berg, S Van Den.]]
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[[Category: Arrowsmith CH]]
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[[Category: Berglund, H.]]
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[[Category: Berglund H]]
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[[Category: Busam, R D.]]
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[[Category: Busam RD]]
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[[Category: Collins, R.]]
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[[Category: Collins R]]
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[[Category: Consortium, Structural Genomics.]]
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[[Category: Dahlgren LG]]
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[[Category: Dahlgren, L G.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Flodin S]]
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[[Category: Flodin, S.]]
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[[Category: Flores A]]
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[[Category: Flores, A.]]
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[[Category: Graslund S]]
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[[Category: Graslund, S.]]
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[[Category: Hammarstrom M]]
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[[Category: Hammarstrom, M.]]
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[[Category: Herman MD]]
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[[Category: Herman, M D.]]
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[[Category: Johansson I]]
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[[Category: Johansson, I.]]
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[[Category: Kallas A]]
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[[Category: Kallas, A.]]
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[[Category: Karlberg T]]
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[[Category: Karlberg, T.]]
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[[Category: Kotenyova T]]
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[[Category: Kotenyova, T.]]
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[[Category: Lehtio L]]
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[[Category: Lehtio, L.]]
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[[Category: Moche M]]
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[[Category: Moche, M.]]
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[[Category: Nilsson ME]]
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[[Category: Nilsson, M E.]]
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[[Category: Nordlund P]]
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[[Category: Nordlund, P.]]
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[[Category: Nyman T]]
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[[Category: Nyman, T.]]
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[[Category: Persson C]]
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[[Category: Persson, C.]]
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[[Category: Sagemark J]]
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[[Category: Sagemark, J.]]
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[[Category: Svensson L]]
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[[Category: Svensson, L.]]
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[[Category: Thorsell AG]]
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[[Category: Thorsell, A G.]]
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[[Category: Tresaugues L]]
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[[Category: Tresaugues, L.]]
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[[Category: Van Den Berg S]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Welin, M.]]
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[[Category: Welin M]]
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[[Category: Wikstrom, M.]]
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[[Category: Wikstrom M]]
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[[Category: Dhp]]
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[[Category: Dhpase]]
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[[Category: Dihydropyrimidinase]]
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[[Category: Dihydropyrimidine amidohydrolase]]
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[[Category: Disease mutation]]
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[[Category: Dpy]]
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[[Category: Hydantoinase]]
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[[Category: Hydrolase]]
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[[Category: Metal-binding]]
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[[Category: Nucleotide metabolism]]
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[[Category: Zinc]]
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[[Category: Zn-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 00:46:25 2009''
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Current revision

Human Dihydropyrimidinase

PDB ID 2vr2

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Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vr2"
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