1ymz

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{{Seed}}
 
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[[Image:1ymz.png|left|200px]]
 
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==CC45, An Artificial WW Domain Designed Using Statistical Coupling Analysis==
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The line below this paragraph, containing "STRUCTURE_1ymz", creates the "Structure Box" on the page.
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<StructureSection load='1ymz' size='340' side='right'caption='[[1ymz]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ymz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YMZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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-->
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ymz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ymz OCA], [https://pdbe.org/1ymz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ymz RCSB], [https://www.ebi.ac.uk/pdbsum/1ymz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ymz ProSAT]</span></td></tr>
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{{STRUCTURE_1ymz| PDB=1ymz | SCENE= }}
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ym/1ymz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ymz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Classical studies show that for many proteins, the information required for specifying the tertiary structure is contained in the amino acid sequence. Here, we attempt to define the sequence rules for specifying a protein fold by computationally creating artificial protein sequences using only statistical information encoded in a multiple sequence alignment and no tertiary structure information. Experimental testing of libraries of artificial WW domain sequences shows that a simple statistical energy function capturing coevolution between amino acid residues is necessary and sufficient to specify sequences that fold into native structures. The artificial proteins show thermodynamic stabilities similar to natural WW domains, and structure determination of one artificial protein shows excellent agreement with the WW fold at atomic resolution. The relative simplicity of the information used for creating sequences suggests a marked reduction to the potential complexity of the protein-folding problem.
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===CC45, An Artificial WW Domain Designed Using Statistical Coupling Analysis===
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Evolutionary information for specifying a protein fold.,Socolich M, Lockless SW, Russ WP, Lee H, Gardner KH, Ranganathan R Nature. 2005 Sep 22;437(7058):512-8. PMID:16177782<ref>PMID:16177782</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<!--
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16177782}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1ymz" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16177782 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_16177782}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1YMZ is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YMZ OCA].
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[[Category: Gardner KH]]
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[[Category: Lee H]]
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==Reference==
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[[Category: Lockless SW]]
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<ref group="xtra">PMID:16177782</ref><references group="xtra"/>
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[[Category: Ranganathan R]]
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[[Category: Gardner, K H.]]
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[[Category: Russ WP]]
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[[Category: Lee, H.]]
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[[Category: Socolich M]]
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[[Category: Lockless, S W.]]
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[[Category: Ranganathan, R.]]
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[[Category: Russ, W P.]]
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[[Category: Socolich, M.]]
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[[Category: Artificial protein]]
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[[Category: Computational design]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 01:06:45 2009''
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Current revision

CC45, An Artificial WW Domain Designed Using Statistical Coupling Analysis

PDB ID 1ymz

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