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2a2j
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="2a2j" size="450" color="white" frame="true" align="right" spinBox="true" caption="2a2j, resolution 2.50Å" /> '''Crystal structure of...) |
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| - | [[ | + | ==Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis== |
| - | + | <StructureSection load='2a2j' size='340' side='right' caption='[[2a2j]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | ''' | + | == Structural highlights == |
| + | <table><tr><td colspan='2'>[[2a2j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A2J FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyridoxal_5'-phosphate_synthase Pyridoxal 5'-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.5 1.4.3.5] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2j OCA], [http://pdbe.org/2a2j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a2j RCSB], [http://www.ebi.ac.uk/pdbsum/2a2j PDBsum], [http://www.topsan.org/Proteins/TBSGC/2a2j TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PDXH_MYCTU PDXH_MYCTU]] Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity).[HAMAP-Rule:MF_01629] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a2/2a2j_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a2j ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The three-dimensional structure of Rv2607, a putative pyridoxine 5'-phosphate oxidase (PNPOx) from Mycobacterium tuberculosis, has been determined by X-ray crystallography to 2.5 A resolution. Rv2607 has a core domain similar to known PNPOx structures with a flavin mononucleotide (FMN) cofactor. Electron density for two FMN at the dimer interface is weak despite the bright yellow color of the protein solution and crystal. The shape and size of the putative binding pocket is markedly different from that of members of the PNPOx family, which may indicate some significant changes in the FMN binding mode of this protein relative to members of the family. | ||
| - | + | Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis.,Pedelacq JD, Rho BS, Kim CY, Waldo GS, Lekin TP, Segelke BW, Rupp B, Hung LW, Kim SI, Terwilliger TC Proteins. 2006 Mar 15;62(3):563-9. PMID:16374842<ref>PMID:16374842</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2a2j" style="background-color:#fffaf0;"></div> | |
| - | == | + | == References == |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Pyridoxal 5'-phosphate synthase]] | [[Category: Pyridoxal 5'-phosphate synthase]] | ||
| - | + | [[Category: Hung, L W]] | |
| - | [[Category: Hung, L | + | [[Category: Kim, C Y]] |
| - | [[Category: Kim, C | + | [[Category: Kim, S I]] |
| - | [[Category: Kim, S | + | [[Category: Lekin, T P]] |
| - | [[Category: Lekin, T | + | [[Category: Pedelacq, J D]] |
| - | [[Category: Pedelacq, J | + | [[Category: Rho, B S]] |
| - | [[Category: Rho, B | + | [[Category: Rupp, B]] |
| - | [[Category: Rupp, B | + | [[Category: Segelke, B W]] |
| - | [[Category: Segelke, B | + | [[Category: Terwilliger, T C]] |
| - | [[Category: Terwilliger, T | + | [[Category: Waldo, G S]] |
| - | [[Category: Waldo, G | + | [[Category: XMTB, Mycobacterium Tuberculosis Structural Proteomics Project]] |
| - | [[Category: XMTB, Mycobacterium | + | [[Category: Beta barrel]] |
| - | [[Category: | + | [[Category: Mycobacterium tuberculosis structural proteomics project]] |
| - | [[Category: | + | [[Category: Oxidoreductase]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: | + | [[Category: Xmtb]] |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis
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Categories: Pyridoxal 5'-phosphate synthase | Hung, L W | Kim, C Y | Kim, S I | Lekin, T P | Pedelacq, J D | Rho, B S | Rupp, B | Segelke, B W | Terwilliger, T C | Waldo, G S | XMTB, Mycobacterium Tuberculosis Structural Proteomics Project | Beta barrel | Mycobacterium tuberculosis structural proteomics project | Oxidoreductase | Structural genomic | Xmtb
