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2i53

From Proteopedia

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{{Seed}}
 
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[[Image:2i53.png|left|200px]]
 
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<!--
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==Crystal structure of Cyclin K==
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The line below this paragraph, containing "STRUCTURE_2i53", creates the "Structure Box" on the page.
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<StructureSection load='2i53' size='340' side='right'caption='[[2i53]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2i53]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I53 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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{{STRUCTURE_2i53| PDB=2i53 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i53 OCA], [https://pdbe.org/2i53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i53 RCSB], [https://www.ebi.ac.uk/pdbsum/2i53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i53 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CCNK_HUMAN CCNK_HUMAN] May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA polymerase II C-terminal domain and CDK2 (CAK).<ref>PMID:10574912</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/2i53_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i53 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of Cyclin K===
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==See Also==
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*[[Cyclin 3D structures|Cyclin 3D structures]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_17169370}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 17169370 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_17169370}}
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==About this Structure==
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2I53 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I53 OCA].
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==Reference==
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<ref group="xtra">PMID:17169370</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Baek, K.]]
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[[Category: Large Structures]]
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[[Category: Birrane, G.]]
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[[Category: Baek K]]
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[[Category: Brown, R S.]]
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[[Category: Birrane G]]
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[[Category: Ladias, J A.A.]]
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[[Category: Brown RS]]
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[[Category: Cdk9]]
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[[Category: Ladias JAA]]
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[[Category: Cell cycle]]
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[[Category: Cyclin box]]
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[[Category: Cyclin k]]
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[[Category: P-tefb]]
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[[Category: Positive transcription elongation factor]]
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[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 01:34:47 2009''
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Current revision

Crystal structure of Cyclin K

PDB ID 2i53

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OCA

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