1fyw

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{{Seed}}
 
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[[Image:1fyw.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR2==
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The line below this paragraph, containing "STRUCTURE_1fyw", creates the "Structure Box" on the page.
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<StructureSection load='1fyw' size='340' side='right'caption='[[1fyw]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fyw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FYW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1fyw| PDB=1fyw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyw OCA], [https://pdbe.org/1fyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fyw RCSB], [https://www.ebi.ac.uk/pdbsum/1fyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fyw ProSAT], [https://www.topsan.org/Proteins/NESGC/1fyw TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TLR2_HUMAN TLR2_HUMAN] Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/1fyw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fyw ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR2===
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==See Also==
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*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11081518}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11081518 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11081518}}
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==About this Structure==
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1FYW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYW OCA].
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==Reference==
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<ref group="xtra">PMID:11081518</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Horng, T.]]
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[[Category: Large Structures]]
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[[Category: Manley, J L.]]
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[[Category: Horng T]]
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[[Category: Medzhitov, R.]]
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[[Category: Manley JL]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Medzhitov R]]
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[[Category: Shen, B.]]
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[[Category: Shen B]]
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[[Category: Tao, X.]]
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[[Category: Tao X]]
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[[Category: Tong, L.]]
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[[Category: Tong L]]
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[[Category: Xu, Y.]]
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[[Category: Xu Y]]
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[[Category: Beta-alpha-beta fold parallel beta sheet]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 01:50:10 2009''
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Current revision

CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR2

PDB ID 1fyw

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