2f94

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{{Seed}}
 
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[[Image:2f94.png|left|200px]]
 
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==Crystal structure of human FPPS in complex with ibandronate==
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The line below this paragraph, containing "STRUCTURE_2f94", creates the "Structure Box" on the page.
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<StructureSection load='2f94' size='340' side='right'caption='[[2f94]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2f94]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F94 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BFQ:IBANDRONATE'>BFQ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2f94| PDB=2f94 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f94 OCA], [https://pdbe.org/2f94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f94 RCSB], [https://www.ebi.ac.uk/pdbsum/2f94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f94 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/2f94_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f94 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human FPPS in complex with ibandronate===
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==See Also==
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*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 16892359 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16892359}}
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==About this Structure==
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2F94 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F94 OCA].
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==Reference==
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<ref group="xtra">PMID:16892359</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bitsch, F.]]
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[[Category: Large Structures]]
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[[Category: Bourgier, E.]]
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[[Category: Bitsch F]]
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[[Category: Geiser, M.]]
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[[Category: Bourgier E]]
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[[Category: Green, J R.]]
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[[Category: Geiser M]]
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[[Category: Hemmig, R.]]
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[[Category: Green JR]]
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[[Category: Jahnke, W.]]
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[[Category: Hemmig R]]
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[[Category: Kroemer, M.]]
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[[Category: Jahnke W]]
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[[Category: Lehmann, S.]]
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[[Category: Kroemer M]]
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[[Category: Ramage, P.]]
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[[Category: Lehmann S]]
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[[Category: Rieffel, S.]]
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[[Category: Ramage P]]
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[[Category: Rondeau, J M.]]
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[[Category: Rieffel S]]
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[[Category: Strauss, A.]]
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[[Category: Rondeau J-M]]
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[[Category: Bisphosphonate inhibitor]]
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[[Category: Strauss A]]
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[[Category: Cholesterol biosynthesis]]
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[[Category: Isoprene biosynthesis]]
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[[Category: Mevalonate pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 01:55:19 2009''
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Current revision

Crystal structure of human FPPS in complex with ibandronate

PDB ID 2f94

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