1x6j

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{{Seed}}
 
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[[Image:1x6j.png|left|200px]]
 
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==Crystal structure of ygfY from Escherichia coli==
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The line below this paragraph, containing "STRUCTURE_1x6j", creates the "Structure Box" on the page.
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<StructureSection load='1x6j' size='340' side='right'caption='[[1x6j]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1x6j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X6J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X6J FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x6j OCA], [https://pdbe.org/1x6j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x6j RCSB], [https://www.ebi.ac.uk/pdbsum/1x6j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x6j ProSAT]</span></td></tr>
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{{STRUCTURE_1x6j| PDB=1x6j | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of ygfY from Escherichia coli===
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[https://www.uniprot.org/uniprot/SDHE_ECOLI SDHE_ECOLI] An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins (PubMed:22474332, PubMed:26644464, PubMed:24374335). Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH (PubMed:24374335, PubMed:26644464, PubMed:22474332). Required for flavinylation of the flavoprotein subunit FdrA of fumarate reductase (FDR) (PubMed:26644464). Binds 2 different sites on the flavoprotein target FrdA (and presumably also SdhA), possibly positioning FAD and protein to facilitate the covalent bond formation; covalent attachment of FAD is not required for SDH or FDR complex enzyme formation (PubMed:26644464). Overexpression of this protein and YgfX (formerly cptA) restores production of prodigiosin antibiotic (Pig) in Serratia strains with deletions of sdhE-ygfX (PubMed:22474332).<ref>PMID:23657679</ref> <ref>PMID:24374335</ref> <ref>PMID:26644464</ref> <ref>PMID:22474332</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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1X6J is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X6J OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x6/1x6j_consurf.spt"</scriptWhenChecked>
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==Reference==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<ref group="xtra">PMID:15593094</ref><references group="xtra"/>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x6j ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Demirkan, E Sarikaya.]]
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[[Category: Large Structures]]
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[[Category: Doseeva, V.]]
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[[Category: Doseeva V]]
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[[Category: Galkin, A.]]
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[[Category: Galkin A]]
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[[Category: Herzberg, O.]]
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[[Category: Herzberg O]]
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[[Category: Howard, A.]]
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[[Category: Howard A]]
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[[Category: Krajewski, W.]]
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[[Category: Krajewski W]]
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[[Category: Lim, K.]]
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[[Category: Lim K]]
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[[Category: Pullalarevu, S.]]
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[[Category: Pullalarevu S]]
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[[Category: S2F, Structure 2.Function Project.]]
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[[Category: Sarikaya Demirkan E]]
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[[Category: Hypothetical protein]]
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[[Category: S2f]]
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[[Category: Structural genomic]]
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[[Category: Structure 2 function project]]
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[[Category: Transcriptional regulation]]
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[[Category: Ygfy]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 02:31:37 2009''
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Current revision

Crystal structure of ygfY from Escherichia coli

PDB ID 1x6j

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