1n46

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[[Image:1n46.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF HUMAN TR BETA LIGAND-BINDING DOMAIN COMPLEXED WITH A POTENT SUBTYPE-SELECTIVE THYROMIMETIC==
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The line below this paragraph, containing "STRUCTURE_1n46", creates the "Structure Box" on the page.
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<StructureSection load='1n46' size='340' side='right'caption='[[1n46]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1n46]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N46 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PFA:[4-(4-HYDROXY-3-ISOPROPYL-PHENOXY)-3,5-DIMETHYL-PHENYL]-6-AZAURACIL'>PFA</scene></td></tr>
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{{STRUCTURE_1n46| PDB=1n46 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n46 OCA], [https://pdbe.org/1n46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n46 RCSB], [https://www.ebi.ac.uk/pdbsum/1n46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n46 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/THB_HUMAN THB_HUMAN] Defects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:[https://omim.org/entry/188570 188570]. GTHR is a disease characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).<ref>PMID:2510172</ref> <ref>PMID:2153155</ref> <ref>PMID:1846005</ref> <ref>PMID:1661299</ref> <ref>PMID:1653889</ref> <ref>PMID:1563081</ref> <ref>PMID:1314846</ref> <ref>PMID:1619012</ref> <ref>PMID:1587388</ref> <ref>PMID:1324420</ref> <ref>PMID:8514853</ref> <ref>PMID:8175986</ref> <ref>PMID:7833659</ref> <ref>PMID:8664910</ref> <ref>PMID:8889584</ref> <ref>PMID:10660344</ref> <ref>PMID:16804041</ref> <ref>PMID:19268523</ref> Defects in THRB are the cause of generalized thyroid hormone resistance autosomal recessive (GTHRAR) [MIM:[https://omim.org/entry/274300 274300]. An autosomal recessive disorder characterized by goiter, clinical euthyroidism, end-organ unresponsiveness to thyroid hormone, abnormal growth and bone maturation, and deafness. Patients also have high levels of circulating thyroid hormones, with elevated thyroid stimulating hormone. Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:[https://omim.org/entry/145650 145650]; also known as familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.<ref>PMID:7528740</ref> <ref>PMID:8381821</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/THB_HUMAN THB_HUMAN] High affinity receptor for triiodothyronine.<ref>PMID:17418816</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n4/1n46_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n46 ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF HUMAN TR BETA LIGAND-BINDING DOMAIN COMPLEXED WITH A POTENT SUBTYPE-SELECTIVE THYROMIMETIC===
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==See Also==
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*[[Thyroid hormone receptor 3D structures|Thyroid hormone receptor 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_12565933}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12565933 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_12565933}}
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==About this Structure==
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1N46 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N46 OCA].
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==Reference==
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<ref group="xtra">PMID:12565933</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ammirati, M J.]]
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[[Category: Large Structures]]
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[[Category: Chiang, P.]]
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[[Category: Ammirati MJ]]
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[[Category: Chrunyk, B A.]]
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[[Category: Chiang P]]
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[[Category: Cornelius, P.]]
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[[Category: Chrunyk BA]]
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[[Category: DaSilva-Jardine, P.]]
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[[Category: Cornelius P]]
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[[Category: Danley, D E.]]
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[[Category: DaSilva-Jardine P]]
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[[Category: Dow, R L.]]
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[[Category: Danley DE]]
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[[Category: Hank, R F.]]
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[[Category: Dow RL]]
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[[Category: Hargrove, D M.]]
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[[Category: Hank RF]]
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[[Category: LeMotte, P K.]]
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[[Category: Hargrove DM]]
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[[Category: Lee, E.]]
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[[Category: LeMotte PK]]
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[[Category: Newsome, W P.]]
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[[Category: Lee E]]
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[[Category: Paight, E S.]]
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[[Category: Newsome WP]]
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[[Category: Pandit, J.]]
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[[Category: Paight ES]]
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[[Category: Patterson, T A.]]
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[[Category: Pandit J]]
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[[Category: Rosner, M H.]]
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[[Category: Patterson TA]]
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[[Category: Schneider, S R.]]
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[[Category: Rosner MH]]
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[[Category: Schulte, G K.]]
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[[Category: Schneider SR]]
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[[Category: Simons, S P.]]
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[[Category: Schulte GK]]
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[[Category: Spitzer, J.]]
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[[Category: Simons SP]]
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[[Category: Swick, A G.]]
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[[Category: Spitzer J]]
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[[Category: Tate, B F.]]
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[[Category: Swick AG]]
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[[Category: Transcription]]
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[[Category: Tate BF]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 02:31:45 2009''
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Current revision

CRYSTAL STRUCTURE OF HUMAN TR BETA LIGAND-BINDING DOMAIN COMPLEXED WITH A POTENT SUBTYPE-SELECTIVE THYROMIMETIC

PDB ID 1n46

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